PHARMACEUTICAL COMPOSITIONS
First Claim
Patent Images
1. A pharmaceutical composition in the form of a bi-layer tablet comprising:
- (1) an immediate release layer comprising;
(a) about 5 mgs to about 20 mgs of promethazine or a pharmaceutically acceptable salt thereof,(b) about 75 mgs to about 150 mgs of silicified microcrystalline cellulose,(c) about 5 mgs to about 20 mgs of croscarmellose sodium, and(d) about 0.2 mgs to about 5 mgs of magnesium stearate; and
(2) a controlled release layer comprising;
(a) about 250 mgs to about 400 mgs of acetaminophen, or a pharmaceutically acceptable salt thereof,(b) about 2 mgs to about 15 mgs of hydrocodone, or a pharmaceutically acceptable salt thereof,(c) about 100 mgs to about 250 mgs of silicified microcrystalline cellulose,(d) about 5 mgs to about 30 mgs of hydroxy methyl propyl cellulose,(e) about 0.5 mgs to about 5 mgs magnesium stearate, and(f) about 0.5 mgs to about 10 mgs stearic acid.
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Accused Products
Abstract
Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.
52 Citations
17 Claims
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1. A pharmaceutical composition in the form of a bi-layer tablet comprising:
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(1) an immediate release layer comprising; (a) about 5 mgs to about 20 mgs of promethazine or a pharmaceutically acceptable salt thereof, (b) about 75 mgs to about 150 mgs of silicified microcrystalline cellulose, (c) about 5 mgs to about 20 mgs of croscarmellose sodium, and (d) about 0.2 mgs to about 5 mgs of magnesium stearate; and (2) a controlled release layer comprising; (a) about 250 mgs to about 400 mgs of acetaminophen, or a pharmaceutically acceptable salt thereof, (b) about 2 mgs to about 15 mgs of hydrocodone, or a pharmaceutically acceptable salt thereof, (c) about 100 mgs to about 250 mgs of silicified microcrystalline cellulose, (d) about 5 mgs to about 30 mgs of hydroxy methyl propyl cellulose, (e) about 0.5 mgs to about 5 mgs magnesium stearate, and (f) about 0.5 mgs to about 10 mgs stearic acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification