EYESIGHT-PROTECTING COMPOSITION CONTAINING FUNCTIONAL COMPONENTS HAVING PREVENTIVE AND THERAPEUTIC EFFICACY IN DIABETES OR DIABETES COMPLICATIONS

• US 20110268827A1
• Filed: 12/23/2009
• Published: 11/03/2011
• Est. Priority Date: 01/08/2009
• Status: Active Grant

• Current Assignee: Konkuk University Glocal-Industry-Academic Collaboration Foundation
• Original Assignee: Konkuk University Industrial Cooperation Corp
• Inventors: Jeon, Yun Hui, Lim, Beong Ou, Jeoung, Young Jun, O, Khan
• Granted Patent: US 8,455,018 B2
• Time in Patent Office: Days
• US Class Current: 424/765
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/51 Thiamines, e.g. vitamin B1
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/593 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 36/481 Astragalus (milkvetch)
• CPC Class Codes: A61K 36/482 Cassia, e.g. golden shower tree
• CPC Class Codes: A61K 36/73 Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• CPC Class Codes: A61K 36/8969 Polygonatum (Solomon's seal)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

A vision-protecting composition with prophylactic and therapeutic activity of diabetes or diabetic complications, comprising calcium, vitamin A, vitamin B, vitamin C and vitamin D as functional ingredients, in combination with at least one herb extract selected from the group consisting of a wolfberry extract, an Astragalus membranaceus extract, a Senna obtusifolia extract, a Polygonatum odoratum var. pluriflorum extract and a Rubus coreanus extract. Found to be significantly suppressive and regulatory of the expression of inflammatory factors, the cytokine expression of Th1/Th2 cells via the JAK-STAT signaling pathway, and the expression of STAT3 in diabetic retinopathy, the composition can be used to protect vision as well as for the prophylaxis or treatment of diabetes and diabetic complications.

Claims

1. A vision-protecting composition with prophylactic and therapeutic activity of diabetes or diabetic complications, comprising calcium, vitamin A, vitamin B, vitamin C and vitamin D as functional ingredients, in combination with at least one herb extract selected from the group consisting of a wolfberry extract, an Astragalus membranaceus extract, a Senna extract, a Polygonatum odoratum var. pluriflorum extract and a Rubus coreanus extract.

2. The vision-protecting composition of claim 1, wherein the calcium is seaweed calcium or a calcium salt of fermented organic acid.

3. The vision-protecting composition of claim 1, wherein the vitamin B is selected from the group consisting of vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12 and a combination thereof.

4. The vision-protecting composition of claim 1, wherein the vitamin B is a combination of vitamins B1, B2, B3, B6 and B12.

5. The vision-protecting composition of claim 1, wherein the vitamin D is vitamin D3.

6. The vision-protecting composition of claim 1, wherein the calcium is contained in an amount of from 4 to 10 wt % based on 100 wt % of the composition.

7. The vision-protecting composition of claim 1, wherein the vitamin A is contained in an amount of from 0.001 to 0.1 wt % based on 100 wt % of the composition.

8. The vision-protecting composition of claim 1, wherein the vitamin C is contained in an amount of from 0.1 to 1 wt % based on 100 wt % of the composition.

9. The vision-protecting composition of claim 1, wherein the vitamin B is contained in an amount of from 0.0001 to 0.1 wt % based on 100 wt % of the composition.

10. The vision-protecting composition of claim 1, wherein the vitamin D is contained in an amount of from 0.001 to 0.5 wt % based on 100 wt % of the composition.

11. The vision-protecting composition of claim 1, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

12. The vision-protecting composition of claim 1, wherein the herb extract is contained in an amount of from 0.1 to 5 wt % based on 100 wt % of the composition.

13. The vision-protecting composition of claim 1, wherein the herb extract is composed of 30 wt % of a wolfberry extract, 27 wt % of an Astragalus membranaceus extract, 25 wt % of a Senna obtusifolia extract, 10 wt % of a Polygonatum odoratum var. pluriflorum extract, and 8 wt % of a Rubus coreanus extract, based on 100 wt % of the composition.

14. The vision-protecting composition of claim 1, wherein the diabetic complication is diabetic retinopathy.

15. The vision-protecting composition of claim 3, wherein the vitamin B is a combination of vitamins B1, B2, B3, B6 and B12.

16. The vision-protecting composition of claim 2, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

17. The vision-protecting composition of claim 3, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

18. The vision-protecting composition of claim 4, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

19. The vision-protecting composition of claim 5, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

20. The vision-protecting composition of claim 6, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

21. The vision-protecting composition of claim 7, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

22. The vision-protecting composition of claim 8, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

23. The vision-protecting composition of claim 9, wherein the vitamin B is composed of 0.0003 wt % of vitamin B1, 0.0005 wt % of vitamin B2, 0.001 wt % of vitamin B3, 0.001 wt % of vitamin B6, and 0.0001 wt % of vitamin B12 based on 100 wt % of the composition.

24. The vision-protecting composition of claim 12, wherein the herb extract is composed of 30 wt % of a wolfberry extract, 2′

7 wt % of an Astragalus membranaceus extract, 25 wt % of a Senna obtusifolia extract, 10 wt % of a Polygonatum odoratum var. pluriflorum extract, and 8 wt % of a Rubus coreanus extract, based on 100 wt % of the composition.