HEPARIN COATINGS

• US 20110274821A1
• Filed: 07/15/2011
• Published: 11/10/2011
• Est. Priority Date: 06/26/2001
• Status: Active Grant

• Current Assignee: BioInteractions Ltd.
• Original Assignee: BioInteractions Ltd.
• Inventors: Luthra, Ajay K., Hudson, John O., Sandhu, Shivpal S.
• Granted Patent: US 9,127,091 B2
• Time in Patent Office: Days
• US Class Current: 427/2.25
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 33/0011 Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
• CPC Class Codes: A61L 33/0064 Hydrogels or hydrocolloids
• CPC Class Codes: C08B 37/0063 Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
• CPC Class Codes: C08B 37/0069 Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
• CPC Class Codes: C08B 37/0075 Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: D04B 21/205 Elongated tubular articles of small diameter, e.g. coverings or reinforcements for cables or hoses
• CPC Class Codes: D10B 2403/0122 Smooth surfaces, e.g. laminated or coated
• CPC Class Codes: D10B 2509/06 Vascular grafts; stents

Abstract

The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example, methacrylates. The macromers may also be made into polymers of at least two macromers polymerized together. These polymers are preferably multi-armed or high-molecular weight and used for medical uses, for example, making coatings on medical devices. Macromers of N-vinylpyrrolidone are also disclosed herein.

Claims

1. A method of preparing a medical device coating comprising exposing the medical device to an aqueous solution comprising a first polymer and a polymeric heat-initiated crosslinker and heating the solution to thereby crosslink the first polymer with the heat-initiated polymeric cross-linker and form the coating on the medical device, wherein the first polymer comprises heparin pendant groups, nucleophilic pendant groups, and carboxylic acid pendant groups.

2. The method of claim 1 wherein the first polymer further comprises sulfate groups and/or sulfonate groups.

3. The method of claim 1 further comprising preparation of the first polymer by a reaction comprising polymerization a heparin macromer.

4. The method of claim 3 wherein the polymerization of the heparin macromer further comprises copolymerization with a polyethylene glycol macromer.

5. The method of claim 3 wherein the medical device is chosen from the group consisting of a wire, a tube, a coil, a spring, stent, catheter, balloon, and an implantable device.

6. The method of claim 3 wherein preparation of the first polymer comprises reacting heparin with a quaternary ammonium salt to form a heparin-quaternary ammonium salt complex and then dissolving said complex in an organic solvent, followed by reaction of the complex with a monomer in the solvent to form the macromer.

7. The method of claim 6 further comprising, before reaction with the medical device, removing the quaternary ammonium salt by exposure to another salt.