METAL COORDINATED COMPOSITIONS
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Abstract
A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.
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69 Claims
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1-47. -47. (canceled)
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48. A metal coordination complex of a biologically active moiety and a metal, wherein:
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the biologically active moiety is selected from the group consisting of Zanamivir, Levofloxacin, Montelukast, Epoetin, Enalapril, Methotrexate, Hydralazine, Metronidazole, Carbergoline, Gentamycin, Tobramycin, Acarbose, interference ribonucleic acid (iRNA), Atorvastatin, Lansoprazole, Losartan, Olanzapine, Gabapentin, Pemetrexed, Tenofovir, Ramipril, Trovafloxacin, and derivatives thereof; and wherein the metal is selected from the group consisting of aluminum, bismuth, calcium, copper, iron, magnesium, silicon, and zinc. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56)
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57. A method of modulating properties of a biologically active moiety comprising:
forming a metal coordination complex of the biologically active moiety with a metal; wherein the biologically active moiety is selected from the group consisting of Zanamivir, Levofloxacin, Montelukast, Epoetin, Enalapril, Methotrexate, Hydralazine, Metronidazole, Carbergoline, Gentamycin, Tobramycin, Acarbose, iRNA, Atorvastatin, Lansoprazole, Losartan, Olanzapine, Gabapentin, Pemetrexed, Tenofovir, Ramipril, Trovafloxacin, and derivatives thereof; and wherein the metal is selected from the group consisting of aluminum, bismuth, calcium, copper, iron, magnesium, silicon, and zinc. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66)
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67. A metal coordination complex of a biologically active moiety and a metal, wherein:
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the biologically active moiety is selected from the group consisting of Zanamivir, Levofloxacin, Montelukast, Epoetin, Enalapril, Methotrexate, Hydralazine, Metronidazole, Carbergoline, Gentamycin, Tobramycin, Acarbose, and derivatives thereof; and wherein the metal is selected from the group consisting of aluminum, bismuth, calcium, copper, iron, magnesium, silicon, and zinc. - View Dependent Claims (68, 69)
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Specification