ASSAY DEVICE AND METHODS
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Abstract
The present invention relates to the use of amphipathic polymers to enhance lateral flow and reagent mixing on assay devices. More specifically, the invention relates to use of an amphipathic polymer in assay methods including a device for determining the concentration of lipids in blood serum or plasma.
29 Citations
84 Claims
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1-47. -47. (canceled)
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48. An assay device for detecting the presence or quantity of an analyte residing in an aqueous sample, the device comprising:
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(i) at least one application area suitable for application of an aqueous sample to the device; (ii) at least one probe, reporter or reagent wherein, in use the at least one probe, reporter or reagent is able to react with an analyte residing in the aqueous sample; (iii) at least one test area wherein, in use the result and/or progress of a reaction between the analyte and the at least one probe, reporter or reagent may be determined; (iv) at least one flow path being in fluid communication with the at least one application area and the at least one test area; wherein the at least one flow path comprises at least one amphipathic polymer that is soluble in water and wherein, in use the passage of fluid along the at least one flow path is greater than that expected by capillary action alone. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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84. A process for enhancing lateral fluid flow in a membrane-free device for point of care use comprising coating a surface along which a fluid may flow with an amphipathic polymer that is soluble in water.
Specification