USE OF THE SPARC MICROENVIRONMENT SIGNATURE IN THE TREATMENT OF CANCER

  • US 20120020959A1
  • Filed: 06/03/2011
  • Published: 01/26/2012
  • Est. Priority Date: 06/03/2010
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating a tumor in an animal with a chemotherapeutic regimen comprising:

  • (a) preparing a plurality of histologic sections of the tumor to obtain SPARC microenvironment signature (SMS),(b) immunostaining a histologic section of the tumor with a first anti-SPARC antibody, wherein the first anti-SPARC antibody preferentially stains SPARC in tumor cells,(c) immunostaining a histologic section of the tumor with a second anti-SPARC antibody, wherein the second anti-SPARC antibody preferentially stains SPARC in fibroblasts,(d) determining the staining of the tumor cells, fibroblast, inflammatory cells, acellular stroma/matrix, blood vessels, nerve tissue, normal anatomy within tumor or any combinations thereof with the first anti-SPARC antibody and the staining of the tumor cells, fibroblast, inflammatory cells, acellular stroma/matrix, blood vessels, nerve tissue, normal anatomy within tumor or any combinations thereof with the second antibody, and(e) administering a therapeutically effective amount of the chemotherapeutic regimen if a predefined SMS is demonstrated by the immunostaining.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×