METHODS OF TREATING IMPAIRED GLUCOSE METABOLISM VIA ADMINISTRATION OF ALGAL BIOMASS
First Claim
1. A method of treating a patient having impaired glucose metabolism, comprising determining the patient has impaired glucose metabolism and administering to the patient an effective regime of Chlorella protothecoides microalgal biomass comprising at least 15% algal oil by dry weight.
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Abstract
The invention is directed to methods of using Chlorella protothecoides microalgal biomass in the treatment of individuals having impaired glucose metabolism. In some cases, the patient has impaired fasting glucose, impaired glucose tolerance, or diabetes. In some methods, algal biomass is used to reduce blood glucose and/or body fat in a subject, or to increase the relative abundance of beneficial gut microflora in a subject. In preferred embodiments, the biomass is derived from Chlorella protothecoides cultures grown heterotrophically in which the algal cells comprise at least 15% algal oil by dry weight.
11 Citations
22 Claims
- 1. A method of treating a patient having impaired glucose metabolism, comprising determining the patient has impaired glucose metabolism and administering to the patient an effective regime of Chlorella protothecoides microalgal biomass comprising at least 15% algal oil by dry weight.
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19. A method of reducing blood glucose in a subject, comprising administering to a subject an effective regime of algal biomass comprising at least 15% algal oil by dry weight, whereby the mean blood glucose level of the subject is reduced relative to the level before administering the regime.
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20. A method of reducing body fat in a subject, comprising determining the subject is in need of a treatment to reduce body fat and then administering to the subject an effective regime of algal biomass comprising at least 15% algal oil by dry weight, whereby the percentage fat of total body weight of the subject is reduced relative to the percentage fat of total body weight before administering the regime.
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21. A method of increasing the relative abundance of beneficial gut microflora in a subject, comprising determining the subject would benefit from a greater abundance of beneficial gut microflora and then administering to the subject an effective regime of Chlorella protothecoides microalgal biomass comprising at least 15% algal oil by dry weight, whereby the relative abundance of beneficial gut microflora is increased as compared to the relative abundance before administering the regime.
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22. A method of treating a patient having impaired glucose metabolism, comprising administering to the patient an effective regime of microalgal biomass comprising at least 15% algal oil by dry weight, wherein the microalgae has no more than one base pair difference in 23S rRNA genomic sequence compared to SEQ ID NO:
- 5 or SEQ ID NO;
6.
- 5 or SEQ ID NO;
Specification