APPARATUS AND METHOD OF REACTING POLYMERS BY EXPOSURE TO UV RADIATION TO PRODUCE INJECTABLE MEDICAL DEVICES

• US 20120041095A1
• Filed: 02/22/2010
• Published: 02/16/2012
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Ladet, Sébastien
• Granted Patent: US 9,375,699 B2
• Time in Patent Office: Days
• US Class Current: 522/108
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: B01J 19/123 Ultraviolet light
• CPC Class Codes: B01J 2219/0888 Liquid-liquid

Abstract

Cross-linked compositions include a first precursor functionalized with a first reactive member and a second precursor functionalized with a second reactive member, the first and second reactive members covalently bonding with each other when exposed to UV radiation. The compositions are useful in a variety of surgical and wound treatment applications.

Claims

1-12. -12. (canceled)

13. A process of forming a cross-linked composition comprising:

mixing a volume of a first precursor functionalized with a first click reactive member and a volume of a second precursor functionalized with a second click reactive member, the first and second click reactive members covalently bonding with each other when exposed to UV radiation into a mixing assembly; and

exposing the mixed first and second precursors to UV radiation.

14. The process of claim 13, wherein the first and second precursor each possess a core made of a biocompatible material.

15. The process of claim 13, wherein the first precursor and optionally the second precursor comprises a polyol core.

16. The process of claim 15, wherein the polyol is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

17. The process of claim 13, wherein the first click reactive member is a thiol group and the second click reactive member is an alkene group.

18. A cross-linked composition comprising a mixture of a volume of a first precursor functionalized with a first click reactive member and a volume of a second precursor functionalized with a second click reactive member, the first and second click reactive members covalently bonding with each other when exposed to UV radiation into a mixing assembly;

and

exposing the mixed first and second precursors to UV radiation.

19. The composition of claim 18, wherein the first and second precursors each possess a core made of a biocompatible material.

20. The composition of claim 18, wherein the first precursor and optionally the second precursor comprises a polyol core.

21. The composition of claim 20, wherein the polyol is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

22. The composition of claim 18, wherein the first click reactive member is a thiol group and the second click reactive member is an alkene group.

23. A medical device comprising a cross-linked composition of claim 18.

24. An apparatus comprising:

a supply assembly configured to maintain and selectively dispense a first precursor functionalized with a first click reactive member and a second precursor functionalized with a second click reactive member, the first and second click reactive members covalently bonding with each other when exposed to UV radiation a mixing assembly configured to mix the first and second precursors in a mixing cavity; and

at least one source of UV radiation positioned to irradiate the mixed first and second precursors.