APPLICATION OF AMERICAN GINSENG TO ENHANCE NEUROCOGNITIVE FUNCTION

• US 20120046239A1
• Filed: 11/03/2011
• Published: 02/23/2012
• Est. Priority Date: 05/04/2009
• Status: Active Grant

• Current Assignee: Naturex SA (Givaudan SA)
• Original Assignee: Naturex SA (Givaudan SA)
• Inventors: Ibarra, Alvin, He, Kan, Scholey, Andrew, Roller, Marc, Dikansky, Jacques
• Granted Patent: US 8,968,800 B2
• Time in Patent Office: Days
• US Class Current: 514/26
• CPC Class Codes: A61K 36/258 Panax (ginseng)
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

Claims

1. A method of enhancing cognitive performance in working memory comprising administering an effective amount of American ginseng extract effective to treat a human subject wherein said American ginseng extract comprises 3 parts of ginsenoside Rb2;

3 parts of ginsenoside Rg1;

22 parts of ginsenoside Re;

61 parts of ginsenoside Rb1;

20 parts of ginsenoside Rc and 16 parts of ginsenoside Rd.

2. The method of claim 1 wherein said American ginseng extract is substantially free of ginsenoside Rf.

3. The method of claim 1 wherein the amount of American ginseng administered comprises about 23.30 mg total ginsenosides.

4. The method of claim 1 wherein the amount of American ginseng administered comprises about 46.60 mg total ginsenosides.

5. The method of claim 1 wherein said cognitive performance in working memory of said human subject is measured by administering a test to said human subject wherein said test is selected from the group consisting of Corsi block task, Numeric Working Memory test, Alphabetic Working Memory test and mixtures thereof.

6. The method of any of claims 5 wherein said human subject is administered said effective amount of said American ginseng extract more than 1 hour before administering said test.

7. A method of enhancing cognitive performance in working memory comprising administering an effective amount of American ginseng extract effective to treat a human subject wherein said American ginseng extract comprises about 0.2% of ginsenoside Rb2;

about 0.2% of ginsenoside Rg1;

about 2.0% of ginsenoside Re;

about 5.0% of ginsenoside Rb1;

about 2.0% of ginsenoside Rc and about 1.4% of ginsenoside Rd.

8. The method of claim 7 wherein said American ginseng extract is substantially free of ginsenoside Rf.

9. The method of claim 7 wherein said cognitive performance in working memory of said human subject is measured by administering a test to said human subject wherein said test is selected from the group consisting of Corsi block task, Numeric Working Memory test, Alphabetic Working Memory test and mixtures thereof.

10. The method of claim 7 wherein said effective amount of American ginseng extract administered comprises about 11.65 mg total ginsenosides;

wherein said human subject is administered said effective amount of said American ginseng extract more than 1 hour before administering said test.

11. The method of claim 7 wherein said effective amount of American ginseng extract administered comprises about 23.30 mg total ginsenosides;

wherein said human subject is administered said effective amount of said American ginseng extract more than 3 hours before administering said test.