Methods for Treating Type 2 Diabetes in Patients Resistant to Previous Treatment with other Anti-Diabetic Drugs Employing an SGLT2 Inhibitor and Compositions Thereof
First Claim
1. A method for treating type 2 diabetes in a mammalian patient who has previously been treated with one or more oral anti-diabetic agents and/or one or more injectable anti-diabetic agents, which previous treatment has failed, which comprises administering to said patient in need of treatment a therapeutically effective amount of an SGLT2 inhibitor.
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Abstract
The invention provides methods for treating a patient having type 2 diabetes who has failed on previous regimens of one or more oral and/or injectable anti-diabetic agents, which include the step of administering a therapeutically effective amount of an SGLT2 inhibitor alone or in combination with another anti-diabetic agent and/or other therapeutic agent to such patient. A pharmaceutical composition containing dapagliflozin or dapagliflozin-S-propylene glycol solvate and one or more diabetic agents and/or other therapeutic agents for use in the methods of the invention is also provided.
28 Citations
15 Claims
- 1. A method for treating type 2 diabetes in a mammalian patient who has previously been treated with one or more oral anti-diabetic agents and/or one or more injectable anti-diabetic agents, which previous treatment has failed, which comprises administering to said patient in need of treatment a therapeutically effective amount of an SGLT2 inhibitor.
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15. A pharmaceutical composition which comprises dapagliflozin or dapagliflozin-PGS and metformin and/or pioglitazone or rosiglitazone, and a pharmaceutically acceptable carrier therefor.
Specification