APPLICATION OF 2, 3 - DIHYDRO-3 - HYDROXYMETHYL -6 - AMINO - [1,4 ] - BENZOXAZINE IN PREPARATION OF DRUGS INDUCING EMBRYONIC STEM CELLS TO DIFFERENTIATE TO VASCULAR ENDOTHELIAL CELLS

• US 20120123116A1
• Filed: 05/10/2011
• Published: 05/17/2012
• Est. Priority Date: 05/20/2010
• Status: Active Grant

• Current Assignee: Shandong University
• Original Assignee: Shandong University
• Inventors: Miao, Junying, Zhao, Baoxiang, Zhang, Shangli, Zhao, Jing, Su, Le, Han, Lei
• Granted Patent: US 9,101,634 B2
• Time in Patent Office: Days
• US Class Current: 544/105
• CPC Class Codes: A61K 31/538 ortho- or peri-condensed with carbocyclic ring systems
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

An application of 2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine in the preparation of drugs inducing embryonic stem cells to differentiate to vascular endothelial cells, wherein the concentration of the 2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine in the preparation of drugs effectively inducing mouse embryonic stem cells to differentiate to vascular endothelial cells is 1˜20 μM. The 2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine provided by the invention lays foundation for preparing and developing drugs inducing embryonic stem cells to differentiate to vascular endothelial cells, can be used as an effective research tool of embryonic stem cells, and can be used for researching on embryonic stem cell differentiation and new molecular mechanisms of blood vessel formation.

Claims

1. The application of 2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine in the preparation of drugs inducing embryonic stem cells to differentiate to vascular endothelial cells.

2. As the application described in the claim 1, wherein the concentration of 2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine which can effectively induce the mouse embryonic stem cells to differentiate to vascular endothelial cells is 1˜

20 μ

M.

3. As the application described in the claim 2, wherein the concentration of 2,3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine which can effectively induce the mouse embryonic stem cells to differentiate to vascular endothelial cells is 10 μ

M.