Method for increasing muscle mass and strength

• US 20120141448A1
• Filed: 11/23/2011
• Published: 06/07/2012
• Est. Priority Date: 11/23/2010
• Status: Active Grant

• Current Assignee: Chemi Nutra
• Original Assignee: Chemi Nutra
• Inventors: De Ferra, Lorenzo, Purpura, Martin, Jäger, Ralf, Heuer, Marvin, Hagerman, Scott
• Granted Patent: US 10,869,843 B2
• Time in Patent Office: Days
• US Class Current: 424/94.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/661 Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61K 38/014 from connective tissue peptides, e.g. gelatin, collagen
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 38/27 Growth hormone [GH], i.e. somatotropin
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 38/30 Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2 insulin-like growth factor binding protein A61K38/1754
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26

Abstract

Phosphatidic acid is administered orally to increase muscle mass and strength in exercising mammals. Phosphatidic acid is administered orally to aging, bedridden or cachectic patients to improve nitrogen balance. The preferred form of phosphatidic acid for administration is phosphatidic acid-enriched lecithin. Creatine is co-administered orally to increase the muscle-building and strength effect. Other suggested additives include nutritional and herbal supplements, micronutrients and hormones.

Claims

1. A method for increasing muscle mass and strength in mammals, the method comprising the oral administration of a therapeutically effective amount of essentially pure phosphatidic acid or phosphatidic acid-enriched lecithin.

2. The method of claim 1 wherein the therapeutically effective amount is 0.1 grams to 40 grams, administered orally one to three times daily.

3. The method of claim 2 wherein the mammal is human and the therapeutically effective amount is 0.5 to 4 grams.

4. The method of claim 2 wherein the mammal is canine and the therapeutically effective amount is 0.1 to 3 grams.

5. The method of claim 2 wherein the mammal is equine and the therapeutically effective amount is 10 to 40 grams

6. The method of claim 1 wherein the therapeutically effective amount is administered to an exercising subject during the anabolic window.

7. The method of claim 6 further comprising the ingestion of 20 to 100 grams of protein during the anabolic window.

8. The method of claim 7 wherein the protein is a complete protein containing all the essential amino acids.

9. The method of claim 7 wherein the protein is whey or partially hydrolyzed collagen protein.

13. The method of claim 1 further comprising the administration of a therapeutically effective amount of creatine.

14. The method of claim 13 wherein the therapeutically effective amount is from 3 to 20 grams.

10. A method for improving the nitrogen balance of an aging, bedridden or cachectic human comprising the administration of a therapeutically effective amount of phosphatidic acid or phosphatidic acid-enriched lecithin.

11. The method of claim 10 wherein the therapeutically effective amount is 0.1 grams to 4 grams, given orally one to four times daily.

12. The method of claim 11 wherein the therapeutically effective amount is administered by parenteral

15. A composition comprising creatine plus phosphatidic acid or phosphatidic acid-enriched lecithin.

16. The composition of claim 15 wherein the phosphatidic acid or phosphatidic acid-enriched lecithin is prepared from a source consisting of soybeans, peanuts, wheat, oats, safflower, fish, milk, bovine liver, eggs and egg yolks.

17. The composition of claim 15 wherein the creatine and phosphatidic acid or phosphatidic acid-enriched lecithin are present in the ratio of about 5 to 3.

18. A method for increasing the response to the administration of creatine consisting of the administration of a therapeutically effective amount of phosphatidic acid or phosphatidic acid-enriched lecithin concomitant with the co-administration of a therapeutically effective amount of creatine to a human subject 1 to 3 times daily.

19. The method of claim 18 wherein the therapeutically effective amount of phosphatidic acid-enriched lecithin is 0.5 to 4 grams and the therapeutically effective amount of creatine is 3 to 10 grams.

20. A method for increasing muscle mass and strength in mammals comprising the administration of a therapeutically effective amount of phosphatidic acid or phosphatidic acid-enriched lecithin plus nutritional supplements.

21. The method of claim 20 wherein the nutritional supplements comprise protein, amino acids, α

-lipoic acids, β

-hydroxy-β

-methyl butyrate, glycine propyline-L-carnatine, carnatine, Russian tarragon, gymnema sylvestre, bitter melon, cissus quadruangularis, cinnamon and fenugreek, leucine peptide, leucine, CLA, tribulus, mulberry, ribose, caffeine, beta alanine, ZMA, betaine, L-aspartic acid and carnosine, alone or in combination.

22. The method of claim 20 wherein the nutritional supplements comprise micronutients selected from the group comprising CoQ10, chromium, magnesium and vanadium.

23. A method for increasing muscle mass and strength in mammals comprising the administration of a therapeutically effective amount of phosphatidic acid or phosphatidic acid-enriched lecithin plus hormones

24. The method of claim 23 wherein the hormones comprise testosterone, human growth hormone, insulin and insulin-like growth factor.