COMPOSITIONS AND METHODS FOR TREATING HERPES SIMPLEX VIRUS

• US 20120172423A1
• Filed: 07/06/2011
• Published: 07/05/2012
• Est. Priority Date: 08/11/2005
• Status: Active Grant

• Current Assignee: Augusta University Research Institute, Inc.
• Original Assignee: Georgia Health Sciences University Research Institute, Inc.
• Inventors: Hsu, Stephen D.
• Granted Patent: US 9,446,017 B2
• Time in Patent Office: Days
• US Class Current: 514/456
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61P 31/22 for herpes viruses

Abstract

Green tea polyphenol compositions and methods of their use in treating herpes simplex virus (HSV) are provided. Representative green tea polyphenols include, but are not limited to (−)-epigallocatechin-3-gallate as well as green tea polyphenols with one on more ester-linked fatty acids.

Claims

1. A method for treating herpes simplex virus (HSV) infection in a subject comprising administering to the subject a composition comprising an effective amount of a green tea polyphenol esterified with a C₁-C₃₀ group in at least one position to treat at least one symptom of HSV infection.

2. The method of claim 1 wherein the green tea polyphenol is (−

)-epigallocatechin-3-gallate esterified at the 4′

position with stearic acid.

3. The method of claim 1 wherein the green tea polyphenol is esterified in at least two positions.

4. The method of claim 1 wherein the subject is human.

5. The method of claim 1 wherein the composition further comprises an anesthetic.

6. The method of claim 1 wherein the composition is formulated for topical administration.

7. The method of claim 1, wherein the composition is formulated for oral administration.

8. The method of claim 1, wherein the green tea polyphenol is selected from the group consisting of (−

)-epicatechin, (−

)-epigallocatechin, (−

)-epicatechin-3-gallate, enantiomers thereof, isomers thereof, and combinations thereof.

9. The method of claim 1, wherein the HSV is HSV-1.

10. A method of treating herpes simplex virus (HSV) in a subject, comprising administering a composition comprising at least two green tea polyphenols independently esterified with a C₁-C₃₀ group, wherein the C₁-C₃₀ group is the same or different.

11. The method of claim 10, wherein the one or more green tea polyphenols are selected from the group consisting of (−

)-epigallocatechin-3-gallate (−

)-epicatechin, (−

)-epigallocatechin, (−

)-epicatechin-3-gallate, enantiomers thereof, isomers thereof, and combinations thereof.

12. The method of claim 10 wherein the subject is human.