PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES

• US 20120190859A1
• Filed: 01/24/2012
• Published: 07/26/2012
• Est. Priority Date: 01/25/2011
• Status: Active Grant

• Current Assignee: Dow Agrosciences LLC (Corteva, Inc.)
• Original Assignee: Dow Agrosciences LLC (Corteva, Inc.)
• Inventors: Zhu, Yuanming, Whiteker, Gregory T., Renga, James M., Arndt, Kim E., Roth, Gary A., Podhorez, David E., West, Scott P., Arndt, Cynthia
• Granted Patent: US 8,754,231 B2
• Time in Patent Office: Days
• US Class Current: 546/289
• CPC Class Codes: C07D 213/78 Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
• CPC Class Codes: C07D 213/79 Acids; Esters
• CPC Class Codes: C07D 213/803 Processes of preparation
• CPC Class Codes: C07D 213/81 Amides; Imides

Abstract

4-Amino-5-fluoro-3-halo-6-(substituted)picolinates are conveniently prepared from 4,5,6-trichloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange, halogenation, nitrile hydrolysis, esterification, and transition metal assisted coupling.

Claims

1. A process for the preparation of a 4-amino-5-fluoro-3-halo-6-(substituted)picolinate of the Formula I

2. A process for the preparation of a 4-amino-5-fluoro-3-halo-6-(substituted)picolinate of the Formula I

3. A process for the preparation of a 4-amino-5-fluoro-3-halo-6-(substituted)picolinate of the Formula I

4. A process for the preparation of a 4-amino-5-fluoro-3-halo-6-(substituted)picolinate of the Formula I