Graft Systems Having Semi-Permeable Filling Structures and Methods for Their Use
First Claim
1. A system for treating an aneurysm in a blood vessel, said system comprising:
- at least a first double-walled filling structure comprising an outer wall, an inner wall, and a fillable space there-between such that when filled, the outer wall conforms to the inside surface of the aneurysm and the inner wall forms a first generally tubular lumen to provide a path for blood flow, wherein the filling structure further comprises a membrane, the membrane permeable to water molecules so as to allow transport of water molecules across the membrane when a water potential differential exists across the membrane; and
a fluid filling medium for filling said fillable space, the fluid filling medium having a dissolvable solute.
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Accused Products
Abstract
Aneurysms are treated by filling at least one double-walled filling structure with a filling medium within the aneurysm, such as filling structures having a membrane that allows water molecules to permeate across the membrane in response to a water potential differential across the membrane. The transport of fluid across the membrane allows the bag to expand or shrink to accommodate changes in the size or shape of the aneurysm, thereby maintaining a seal between the filling structure against the vessel wall and maintaining apposition of the filling structure against the inside surface of the aneurysm. Transport of water molecules into or out of the filling structure is controlled by adjusting for the osmolarity of the filling fluid medium. The filling structures may be delivered over balloon deployment mechanisms in order to shape occlude the aneurysm and open a tubular lumen for flow of blood through the filling structure.
54 Citations
21 Claims
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1. A system for treating an aneurysm in a blood vessel, said system comprising:
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at least a first double-walled filling structure comprising an outer wall, an inner wall, and a fillable space there-between such that when filled, the outer wall conforms to the inside surface of the aneurysm and the inner wall forms a first generally tubular lumen to provide a path for blood flow, wherein the filling structure further comprises a membrane, the membrane permeable to water molecules so as to allow transport of water molecules across the membrane when a water potential differential exists across the membrane; and a fluid filling medium for filling said fillable space, the fluid filling medium having a dissolvable solute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A self-adjusting endograft for treating an aneurysm in a blood vessel, said endograft comprising:
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a generally tubular lumen to provide a path for blood flow body through the endograft; a fillable component having a fillable space in fluid communication with an exterior environment surrounding the endograft across a semi-permeable membrane; wherein the semi-permeable membrane allows transfer of fluid into the fillable space when a water potential within the fillable space is less than a water potential of an environment directly outside the endograft; wherein the semi-permeable membrane allows flow of fluid out from the fillable space when the water potential within the fillable space is greater than the water potential of an environment directly outside the endograft; and an outer wall adapted to conform to the inside surface of the aneurysm when the fillable space is filled.
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16. A method for treating an aneurysm, said method comprising:
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positioning at least a first double-walled filling structure across the aneurysm, the filling structure comprising a fillable space in fluid communication with an external environment surrounding the structure through a semi-permeable membrane; filling the space with a fluid filling medium so that the outer wall conforms to and contacts an inside surface of the aneurysm and an inner wall forms a first generally tubular lumen to provide a first blood flow path across the aneurysm; maintaining apposition of the outer wall with the inside surface of the aneurysm through controlled fluid transfer across the semi-permeable between the fillable space and the external environment. - View Dependent Claims (17, 18, 19, 20, 21)
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Specification