Method and Device for the Optical Spectroscopic Identification of Cervical Cancer
First Claim
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1. A medical examination device comprising:
- an illumination source, wherein the illumination source includes a lamp and a light directing device for selectably directing a beam of light from the lamp in either a first beam direction or in a second beam direction;
a visualization unit that receives the beam of light directed in the first beam direction from the illumination source and radiates a macroscopic tissue site with the received beam of light, the visualization unit visualizes a first macroscopic image of a first macroscopic view of the macroscopic tissue site from the light emanating from the tissue illuminated with the beam of light directed in the first beam direction;
a fiber optic probe having a shaft, a handle, and a fiber optic bundle having a plurality of excitation fiber optic strands and a collection fiber optic strand, the excitation fibers and the collection fiber transversing the fiber optic probe from a proximal end of the probe to a distal end of the probe, wherein a proximal end of the excitation fiber optic strands of the probe are optically coupled to the beam of light whenever the beam of light is directed in the second beam direction and wherein the proximal end of the excitation fiber optic strands at the proximal end of the probe collects the coupled beam of light and transmits the beam of light through the excitation fiber optic strands to the distal end of the excitation fiber optic strands at the distal end of the probe to illuminate a selected microscopic tissue area in contact with the distal end of the fiber optic probe, and wherein a distal end of the collection fiber optic strand collects a second emitted light beam emanating from the microscopic tissue area illuminated with the beam of light transmitted by the excitation fiber optic strands and transmits the second emitted light beam to a proximal end of the collection fiber optic strand at the proximal end of the probe;
a detector in optical communication with the proximal end of the collection fiber optic strand, wherein the detector detects a plurality of emission wavelengths in the second emitted light beam; and
a processor for calculating from the detected plurality of emission wavelengths a probability that the tissue is diseased.
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Abstract
A medical examination device used for the detection of pre-cancerous and cancerous tissue has an illumination source, a visualization unit, a contacting optical probe, a detector and a process unit. One embodiment of the apparatus includes both a non-contacting macroscopic viewing device (the visualization unit) for visualizing an interior surface of the cervix, as well as a fiber optic wand (contacting optical probe) for spectrally analyzing a microscopic view of the tissue.
13 Citations
21 Claims
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1. A medical examination device comprising:
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an illumination source, wherein the illumination source includes a lamp and a light directing device for selectably directing a beam of light from the lamp in either a first beam direction or in a second beam direction; a visualization unit that receives the beam of light directed in the first beam direction from the illumination source and radiates a macroscopic tissue site with the received beam of light, the visualization unit visualizes a first macroscopic image of a first macroscopic view of the macroscopic tissue site from the light emanating from the tissue illuminated with the beam of light directed in the first beam direction; a fiber optic probe having a shaft, a handle, and a fiber optic bundle having a plurality of excitation fiber optic strands and a collection fiber optic strand, the excitation fibers and the collection fiber transversing the fiber optic probe from a proximal end of the probe to a distal end of the probe, wherein a proximal end of the excitation fiber optic strands of the probe are optically coupled to the beam of light whenever the beam of light is directed in the second beam direction and wherein the proximal end of the excitation fiber optic strands at the proximal end of the probe collects the coupled beam of light and transmits the beam of light through the excitation fiber optic strands to the distal end of the excitation fiber optic strands at the distal end of the probe to illuminate a selected microscopic tissue area in contact with the distal end of the fiber optic probe, and wherein a distal end of the collection fiber optic strand collects a second emitted light beam emanating from the microscopic tissue area illuminated with the beam of light transmitted by the excitation fiber optic strands and transmits the second emitted light beam to a proximal end of the collection fiber optic strand at the proximal end of the probe; a detector in optical communication with the proximal end of the collection fiber optic strand, wherein the detector detects a plurality of emission wavelengths in the second emitted light beam; and a processor for calculating from the detected plurality of emission wavelengths a probability that the tissue is diseased. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A medical examination device comprising:
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an illumination source, wherein the illumination source includes a lamp and a plurality of selectably engageable filters, the lamp generates a beam of light and one of the selectably engageable filters is used to filter the beam of light to a selected wavelength; a light directing device for selectably directing the entire beam of light from the lamp in either a first beam direction or in a second beam direction; a visualization unit that optically directs the beam of light whenever the beam of light is directed in the first beam direction to illuminate a macroscopic tissue site with the directed beam of light, the visualization unit comprising an optical component that collects a first emitted light beam emanating from the tissue illuminated with the directed beam of light for a direct visualization of a macroscopic view of the illuminated macroscopic tissue site by a user of the examination device; a fiber optic probe having a shaft, a handle, and a fiber optic bundle having a plurality of excitation fiber optic strands and a collection fiber optic strand, wherein the excitation strands of the probe are optically coupled to the beam of light whenever the beam of light is directed in the second beam direction and wherein the excitation fiber optic strands transmit the beam of light to a selected microscopic tissue area, and wherein the collection fiber optic strand collects a second emitted light beam emanating from the microscopic tissue area illuminated with the beam of light transmitted by the excitation fiber optic strands; a detector for detecting a plurality of emission wavelengths from the second emitted light beam; a processor in communication with the illumination source, the light directing device, the fiber optic probe, and the detector; and a user interface unit in communication with the processor, wherein the user interface unit informs the processor to selectably direct the beam of light in the first beam direction or in the second beam direction and to selectably activate the visualization unit or the fiber optic probe. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of detecting cervical cancer comprising the steps of:
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generating a beam of light from an illumination source having a first desired wavelength; directing the first desired wavelength of light to a visualization unit; illuminating a portion of a cervix with the first desired wavelength directed to the visualization unit; visualizing the illuminated portion of the cervix; selecting a microscopic tissue site within the macroscopic view for further investigation; watching the placement of a distal end of a fiber optic probe in contact with the selected microscopic tissue site through the visualization unit; generating a set of selected wavelengths of light by sequentially engaging a set of filters to filter the beam of light from the illumination source; activating a light directing device to direct the set of wavelengths to the fiber optic probe having a plurality of excitation optic fibers and a collection optic fiber; sequentially transmitting the set of wavelengths though the excitation fibers to illuminate the selected microscopic tissue site; collecting an emitted light beam emanating from the illuminated microscopic tissue site through the collection fiber for each transmitted wavelength; transmitting each emitted light beam to a spectrometer; conducting a spectral analysis of each emitted light beam using the spectrometer; and calculating a probability that the selected tissue site is cancerous by comparing the spectral analysis of the selected microscopic tissue site to a spectral analysis of a known non-cancerous tissue site.
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Specification