Method and Apparatus for Producing Autologous Thrombin

• US 20120228203A1
• Filed: 05/25/2012
• Published: 09/13/2012
• Est. Priority Date: 03/06/2009
• Status: Active Grant

• Current Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Biomet Biologics LLC (Zimmer Biomet Holdings, Inc.)
• Inventors: Hecker, Barry F., Leach, Michael D.
• Granted Patent: US 8,783,470 B2
• Time in Patent Office: Days
• US Class Current: 210/179
• CPC Class Codes: C07K 1/34 by filtration, ultrafiltration or reverse osmosis
• CPC Class Codes: C12N 9/6429 Thrombin (3.4.21.5)
• CPC Class Codes: C12Y 304/21005 Thrombin (3.4.21.5)

Abstract

A device for isolating a component of a multi-component composition. The device includes a housing, a chamber, and a withdrawal port. The chamber is rotatably mounted within the housing. The chamber includes a chamber base and a sidewall. The side wall extends from the chamber base. At least a portion of the sidewall is defined by a filter that permits passage of a first component of the multi-component composition out of the chamber through the filter and to the housing base. The filter restricts passage of a second component of the multi-component composition through the filter. The withdrawal port extends from a position proximate to the housing base to an exterior of the device. The withdrawal port permits the withdrawal of the first component from the housing base to an exterior of the device.

Claims

1. A device for isolating a component of a multi-component composition comprising:

a housing having a housing base;

a chamber rotatably mounted within said housing, said chamber including;

a chamber base; and

a side wall extending from said chamber base, at least a portion of said sidewall is defined by a filter that permits passage of a first component of said multi-component composition out of said chamber through said filter and to said housing base, said filter restricts passage of a second component of said multi-component composition through said filter; and

a withdrawal port that extends from a position proximate to said housing base to an exterior of said device, said withdrawal port permits the withdrawal of the first component from the housing base to an exterior of said device.

2. The device of claim 1, further comprising a torque generating device;

and

said chamber further comprising a drive receptor that cooperates with a motor connector of said torque generating device to transfer torque from said torque generating device to said chamber.

3. The device of claim 1, wherein said housing base includes a first sloped portion, a second sloped portion, and an apex portion between said first sloped portion and said second sloped portion;

wherein said first sloped portion slopes toward a sidewall of said housing and said second sloped portion slopes away from said sidewall of said housing; and

wherein said withdrawal port extends from a position proximate to said first sloped portion.

4. The device of claim 3, further comprising an annular rim that extends from an undersurface of said chamber, said annular rim is proximate to said apex portion between said sidewall and said apex portion, said annular rim prevents said first component from passing over said apex portion.

5. The device of claim 1, wherein said chamber further comprises a fixed mixing paddle having a main portion that extends along an axis of rotation of said chamber and having two extending portions that extend from said main portion at about 180°

, each of said extending portions include fins that protrude from said extending portions at right angles.

6. The device of claim 1, wherein said chamber includes a chamber cover and said housing includes a housing cover.

7. The device of claim 6, further comprising a first inlet assembly and a second inlet assembly, wherein said first inlet assembly and said second inlet assembly each extend through said housing cover and said chamber cover to provide a passageway from an exterior of said device to within said chamber, each of said first inlet assembly and said second inlet assembly include a removable inlet tube that prevent rotation of said chamber when inserted within said passageway.

8. The device of claim 2, wherein said torque generating device includes a heater for heating contents of said chamber.

9. The device of claim 1, further comprising glass beads and polyacrylimide beads within said chamber.

10. The device of claim 1, wherein said multi-component composition includes whole blood and said component isolated from said multi-component composition includes thrombin.

11. The device of claim 1, wherein said multi-component composition includes plasma and said component isolated from said multi-component composition includes thrombin.

12. The device of claim 1, wherein said multi-component composition includes platelet rich plasma concentrate and said component isolated from said multi-component composition includes thrombin.

13. The device of claim 1, wherein said filter includes openings sized to permit passage of the first component and restrict passage of the second component;

and

wherein said openings have a width of about 15 μ

m.

14. The device of claim 1, wherein said filter includes a polyester.

15. The device of claim 1, wherein said filter includes a polyethylene terephthalate monofilament.

16. The device of claim 1, wherein said filter includes a twill weave pattern.

17. The device of claim 1, wherein said filter includes a wire diameter of about 37 μ

m.

18. The device of claim 1, wherein said filter includes a thickness of about 55 μ

m.

19. A device for isolating a component of a multi-component composition comprising:

a housing having a housing base;

a chamber rotatably mounted within the housing, the chamber including;

a chamber base;

a chamber cover; and

a side wall extending from the chamber base to the chamber cover, at least a portion of the side wall is defined by a filter proximal the chamber cover that permits passage of a first component of the multi-component composition out of the chamber through the filter into the housing base, the filter restricts passage of a second component of the multi-component composition through the filter; and

a withdrawal port that extends from a position proximate to the housing base to an exterior of the device, the withdrawal port permits withdrawal of the first component from the housing between an inner wall of the housing and the chamber to the exterior of the device.

20. A device for isolating a component of a multi-component composition comprising:

a housing having a housing base, the housing base including a first sloped portion, a second sloped portion, and an apex portion between the first sloped portion and the second sloped portion, where the first sloped portion slopes toward a side wall of the housing and the second slope portion slopes away from the side wall of the housing;

a chamber rotatably mounted within the housing, the chamber including;

a chamber base;

a side wall extending from the chamber base, at least a portion of the sidewall defining a plurality of passages to permit passage of a first component of the multi-component composition out of the chamber through the plurality of passages into the housing base; and

an annular rim that extends from an undersurface of the chamber, the annular rim proximate to the apex portion between the side wall and the apex portion; and

a withdrawal port that extends from a position proximate to the housing base to an exterior of the device, the withdrawal port permits the withdrawal of the first component from the housing base to an exterior of the device.