POSTURE-DEPENDENT STIMULATION FOR IMPLANTABLE STIMULATORS

• US 20120232614A1
• Filed: 02/14/2012
• Published: 09/13/2012
• Est. Priority Date: 03/10/2011
• Status: Active Grant

• Current Assignee: Biotronik SE & Company KG
• Original Assignee: Biotronik SE & Company KG
• Inventors: Bloemer, Frank
• Granted Patent: US 8,818,516 B2
• Time in Patent Office: Days
• US Class Current: 607/46
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36535 controlled by body position or posture

Abstract

A therapeutic stimulator, e.g., a spinal neurostimulator for pain relief, adapts stimulation delivered to the patient in dependence on measurements of patient orientation (e.g., from a three-axis accelerometer), and also on impedance measurements from leads situated within or upon the patient'"'"'s body (e.g., from electrodes on neurostimulation leads extending alongside the spine). Since the impedance measurements can provide additional data regarding body positioning, as well as providing data regarding electrode status (such as lead migration, electrode encapsulation, etc.), use of the impedance measurements can provide more refined (and more appropriate) control of delivered stimulation.

Claims

1. An implantable stimulator including:

a. a stimulation generator configured to deliver electrical stimulation to an electrode of an electrode-bearing lead;

b. a lead impedance sensor configured to determine the impedance of the electrode of the electrode-bearing lead;

c. an orientation sensor configured to provide an orientation output signal indicative of the orientation of the orientation sensor;

d. a controller configured to adjust the electrical stimulation delivered by the stimulation generator in dependence on;

(1) the orientation output signal from the orientation sensor, and

(2) the impedance of the electrode.

2. The implantable stimulator of claim 1 further including a memory storing impedance vectors, each impedance vector encoding:

a. the orientation output signal from the orientation sensor, and

b. the impedance of the electrode, obtained at least substantially at the same time.

3. The implantable stimulator of claim 2 wherein each impedance vector encodes the impedances of two or more electrodes from an electrode-bearing lead.

4. The implantable stimulator of claim 2 wherein each impedance vector encodes the impedances from electrodes on two or more electrode-bearing leads.

5. The implantable stimulator of claim 2 wherein each impedance vector encodes the impedances from six or more electrodes, the electrodes being situated on two or more electrode-bearing leads, each lead bearing at least eight electrodes.

6. The implantable stimulator of claim 2 wherein the memory further stores stimulation parameters, each stimulation parameter:

a. corresponding to an impedance vector, and

b. defining the electrical stimulation to be delivered by the stimulation generator.

7. The implantable stimulator of claim 1 in combination with an input device:

a. in communication with the implantable stimulator, and

b. configured to accept a stimulation parameter which defines the electrical stimulation delivered by the stimulation generator in response to;

(1) the orientation output signal from the orientation sensor, and

(2) the impedance of the electrode.

8. The implantable stimulator of claim 7 wherein the input device is in wireless communication with the implantable stimulator.

9. The implantable stimulator of claim 1 further including:

a. an input device configured to accept a stimulation parameter, wherein the stimulation parameter defines the electrical stimulation delivered by the stimulation generator;

b. a memory storing an association between the stimulation parameter and;

(1) the impedance of the electrode at the time of acceptance of the stimulation parameter, and

(2) the orientation output signal at the time of acceptance of the stimulation parameter;

wherein the controller is further configured to adjust the electrical stimulation delivered by the stimulation generator to the electrical stimulation defined by the stimulation parameter if;

i. the impedance of the electrode is at least approximately equal to the impedance of the electrode at the time of acceptance of the stimulation parameter, and

ii. the orientation output signal is at least approximately equal to the orientation output signal at the time of acceptance of the stimulation parameter.

10. The implantable stimulator of claim 9:

a. further including an implant housing at least partially surrounding;

(1) the stimulation generator,

(2) the lead impedance sensor,

(3) the orientation sensor, and

(4) an implant transceiver configured to wirelessly receive communications from the input device;

b. wherein the input device is separate and spaced from the implant housing.

11. A method for delivering electrical stimulation from an implantable stimulator having a stimulation generator, a lead impedance sensor, an orientation sensor, and a controller, the method including the steps of:

a. delivering electrical stimulation from the stimulation generator to an electrode of an electrode-bearing lead;

b. determining the impedance of the electrode of the electrode-bearing lead via the lead impedance sensor;

c. obtaining an orientation output signal from the orientation sensor, the orientation output signal being indicative of the orientation of the orientation sensor;

d. adjusting the electrical stimulation delivered by the stimulation generator via the controller, the electrical stimulation being adjusted in dependence on;

(1) the orientation output signal from the orientation sensor, and

(2) the impedance of the electrode.

12. The method of claim 11 wherein the step of adjusting the electrical stimulation delivered by the stimulation generator includes:

a. comparing;

(1) the orientation output signal from the orientation sensor, and

(2) the impedance of the electrode, to stored impedance vectors, each impedance vector having a stimulation parameter associated therewith, wherein each stimulation parameter defines the electrical stimulation to be delivered by the stimulation generator;

b. adjusting the electrical stimulation delivered by the stimulation generator in accordance with the stimulation parameter of the impedance vector most closely corresponding to;

(1) the orientation output signal from the orientation sensor, and

(2) the impedance of the electrode.

13. The method of claim 11 further including the step of storing impedance vectors in a memory, each impedance vector encoding:

a. the orientation output signal from the orientation sensor, and

b. the impedance of the electrode at or near the time of the orientation output signal.

14. The method of claim 13 further including the step of storing stimulation parameters in the memory, each stimulation parameter:

a. corresponding to one of the impedance vectors, and

b. defining the electrical stimulation to be delivered by the stimulation generator.

15. The method of claim 13 further including the step of obtaining a stimulation parameter from a user input device, wherein the stimulation parameter defines the electrical stimulation delivered by the stimulation generator in response to:

a. the orientation output signal from the orientation sensor, and

b. the impedance of the electrode.

16. The method of claim 11 further including the steps of:

a. obtaining a stimulation parameter, wherein the stimulation parameter defines the electrical stimulation delivered by the stimulation generator;

b. defining an association between the stimulation parameter and;

(1) the impedance of the electrode at the time the stimulation parameter was obtained, and

(2) the orientation output signal at the time the stimulation parameter was obtained;

c. subsequently adjusting the stimulation generator to deliver electrical stimulation corresponding to the stimulation parameter if;

(1) the impedance of the electrode is at least approximately equal to the impedance of the electrode at the time the stimulation parameter was obtained, and

(2) the orientation output signal is at least approximately equal to the orientation output signal at the time the stimulation parameter was obtained.

17. An implantable stimulator including:

a. a lead bearing an electrode;

b. a lead impedance sensor measuring the impedance of the electrode;

c. an orientation sensor measuring the orientation of the implantable stimulator;

d. a stimulation generator;

(1) connected in communication with the electrode, and

(2) generating electrical stimulation signals dependent on;

(i) the measured orientation of the implantable stimulator, and

(ii) the measured impedance of the electrode.

18. The implantable generator of claim 17:

a. further including a memory storing data relating;

(1) implantable stimulator orientations,

(2) electrode impedances, and

(3) electrical stimulation signals;

b. wherein the stimulation generator generates electrical stimulation signals from;

(1) the measured orientation of the implantable stimulator, and

(2) the measured impedance of the electrode, in accordance with the stored data.

19. The implantable generator of claim 17 in combination with an input device separate from the implantable stimulator, the input device being configured to collect programmer input of data relating:

a. implantable stimulator orientations,

b. electrode impedances, and

c. electrical stimulation signals.

20. The implantable generator of claim 17 wherein:

a. the implantable stimulator includes one or more leads wherein each lead bears one or more electrodes;

b. the stimulation generator generates electrical stimulation signals dependent on;

(1) the measured orientation of the implantable stimulator, and

(2) the measured impedances of three or more of the electrodes.