FUSION PROTEIN REGULATING PLASMA GLUCOSE AND LIPID, ITS PREPARATION METHOD AND USE

  • US 20120238496A1
  • Filed: 03/12/2010
  • Published: 09/20/2012
  • Est. Priority Date: 08/20/2009
  • Status: Active Grant
First Claim
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1. A fusion protein regulating plasma glucose and lipid, wherein the peptide chain is conjugated from N- to C-terminal as followings:

  • R1-R2, R2-R1, R1-L-R2 or R2-L-R1;

    wherein, R1 is human fibroblast growth factor 21, or mutants or active fragments thereof;

    R2 is glucagon-like-peptide-1 or analogues thereof, or mutants or active fragments thereof; and

    L is a linker.

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