FUSION PROTEIN REGULATING PLASMA GLUCOSE AND LIPID, ITS PREPARATION METHOD AND USE
First Claim
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1. A fusion protein regulating plasma glucose and lipid, wherein the peptide chain is conjugated from N- to C-terminal as followings:
- R1-R2, R2-R1, R1-L-R2 or R2-L-R1;
wherein, R1 is human fibroblast growth factor 21, or mutants or active fragments thereof;
R2 is glucagon-like-peptide-1 or analogues thereof, or mutants or active fragments thereof; and
L is a linker.
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Abstract
Provided is a fusion protein, which comprises human fibroblast growth factor 21 and glucagon-like-peptide-1 or its analogs. Also provided is the medicament composition comprising the fusion protein, which can be used for treating or preventing obesity, diabetes, hyperglycemia and hyperlipidemia etc.
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20 Claims
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1. A fusion protein regulating plasma glucose and lipid, wherein the peptide chain is conjugated from N- to C-terminal as followings:
- R1-R2, R2-R1, R1-L-R2 or R2-L-R1;
wherein, R1 is human fibroblast growth factor 21, or mutants or active fragments thereof;
R2 is glucagon-like-peptide-1 or analogues thereof, or mutants or active fragments thereof; and
L is a linker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- R1-R2, R2-R1, R1-L-R2 or R2-L-R1;
Specification