Oligomeric Compounds For The Modultion of HIF-1A Expression
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Abstract
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIF-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
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45 Claims
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1-36. -36. (canceled)
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37. A method of treating a mammal suffering from cancer, comprising administering to the mammal a composition comprising a therapeutically effective amount of an oligonucleotide compound targeted to Hif-1alpha and having the base sequence set forth in SEQ ID NO:
- 3 and an agent selected from the group consisting of an antiinflammatory agent, a corticosteroid, an antiviral agent, a chemotherapeutic agent, and an immuno-modulating agent, wherein the cancer is selected from the group consisting of kidney cancer, melanoma, glioblastoma and prostate cancer, and wherein the oligonucleotide compound comprises one or more LNA units.
- View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45)
Specification