SYSTEMS AND METHODS FOR A COMPUTATIONAL MEDICAL DEVICE IN DYNAMIC BODY SYSTEMS

• US 20120271168A1
• Filed: 04/20/2012
• Published: 10/25/2012
• Est. Priority Date: 08/16/2008
• Status: Active Grant

• Current Assignee: Agathos Holdings LLC
• Original Assignee: Agathos Holdings LLC
• Inventors: Radojicic, Milan
• Granted Patent: US 9,463,276 B2
• Time in Patent Office: Days
• US Class Current: 600/439
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/032 Spinal fluid pressure
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2202/0464 Cerebrospinal fluid
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A computational catheter device including at least one lumen, pressure sensor(s), external sensor(s), a signal modeler, and a signal analyzer is provided. The pressure sensor generates a pressure signal for a dynamic body system, whereas the external sensor determines the fundamental frequency caused by cardiovascular pulsation or external oscillator. The signal modeler uses catheter location and the fundamental frequency to generate a predicted signal. This predicted signal may be compared to the actual pressure signal by the signal analyzer to generate a calibration. This calibration may include any of a measure of perivascular state, a waveform output which causes standing waves within the dynamic body system, a boundary condition for safe operations, and an indication of abnormal physiology for assistance in catheter navigation. The catheter device may also include an actuator which uses the calibration to achieve homeostasis by fluxing fluids and/or guiding catheter movements.

Claims

1. A computational catheter device, useful in association with a dynamic body system, the computational catheter device comprising:

at least one lumen;

at least one pressure sensor configured to generate a pressure signal for a dynamic body system;

at least one external sensor configured to collect a fundamental frequency generated by at least one of a cardiovascular pulsation and external oscillator;

a signal modeler configured to generate a predicted signal using the collected fundamental frequency; and

a signal analyzer configured to compare the predicted signal to the pressure signal and generate a calibration based upon the comparison.

2. The computational catheter device of claim 1, further comprising a micro-surgical tool port configured to couple to at least one microsurgical tool.

3. The computational catheter device of claim 1, further comprising a computational circuit configured to define a compliance curve based upon the calibration, wherein the compliance curve defines safe working parameters for at least one of drug delivery, catheter movements, dialysis, fluid delivery, fluid removal, and fluid exchange.

4. The computational catheter device of claim 1, wherein the at least one pressure sensor is at least one multi-sensor array, and wherein the at least one multi-sensor array includes at least one of a flow meter, chemical sensor, antibody sensor, electrical resistance sensor, spectrographic sensor, and differential pressure sensor.

5. The computational catheter device of claim 1, further comprising at least one fluid pathways coupled to the at least one lumen.

6. The computational catheter device of claim 1, further comprising at least one actuator coupled to a computational circuit, wherein the computational circuit utilizes the calibration and the at least one actuator to achieve homeostasis.

7. The computational catheter device of claim 1, further comprising at least one collapsible member.

8. The computational catheter device of claim 1, further comprising a transducer configured to transmit energy, wherein the energy transmitted may be one of ultrasound energy or electromagnetic energy.

9. The computational catheter device of claim 1, wherein the calibration is a measure of perivascular state.

10. The computational catheter device of claim 1, wherein the calibration is a waveform output which causes standing waves within the dynamic body system.

11. The computational catheter device of claim 1, wherein the calibration is a boundary condition for safe operations.

12. The computational catheter device of claim 1, wherein the calibration provides indication of abnormal physiology for assistance in catheter navigation.

13. A method for generating a calibration for a computational catheter device, useful in association with a dynamic body system, the method comprising:

measuring a pressure signal for a dynamic body system;

measuring a fundamental frequency generated by at least one of a cardiovascular pulsation and external oscillator;

generating a predicted signal using the measured fundamental frequency; and

generating a calibration by comparing the predicted signal to the pressure signal.

14. The method of claim 13, further comprising monitoring movement of a catheter with a known volume, wherein movement is determined over the cardiac cycle and is determined by the calibration in relation to fluid displacement by the known volume.

15. The method of claim 13, further comprising fluxing a fluid to achieve homeostasis, wherein volume of the fluid is based upon the calibration.

16. The method of claim 13, further comprising defining a compliance curve based upon the calibration, wherein the compliance curve defines safe working parameters for drug delivery and catheter movements.

17. The method of claim 13, further comprising generating a standing wave within the dynamic body system by producing feedback to pulsatile pressure changes in the dynamic body system, wherein the feedback is based upon the calibration.

18. The method of claim 13, further comprising generating a safe operational parameter based upon the calibration.

19. The method of claim 13, further comprising identifying obstructions in a fluid pathway utilizing the calibration.

20. A catheter device, useful in association with a dynamic body system, the catheter device comprising:

at least one lumen; and

at least one sensor array configured to generate at least a pressure signal for a dynamic body system, wherein the sensor array is configured to couple to a signal analyzer for comparison to a predicted signal.

21. The catheter device of claim 20, further comprising a micro-surgical tool port configured to couple to at least one microsurgical tool.

22. The catheter device of claim 20, wherein the at least one sensor array includes at least one of a flow meter, chemical sensor, antibody sensor, electrical resistance sensor, spectrographic sensor, and differential pressure sensor.

23. The catheter device of claim 20, further comprising at least one fluid pathways coupled to the at least one lumen.

24. The catheter device of claim 20, further comprising at least one collapsible member.

25. The catheter device of claim 20, further comprising a transducer configured to transmit energy, wherein the energy transmitted may be one of ultrasound energy or electromagnetic energy.

26. A method of using the catheter device of claim 20 in the presence of at least one of unstable plaque, scarring and flow obstructions, wherein the at least one sensor array provides pressure or flow data in order to assist in navigating the at least one of unstable plaque, scarring and flow obstructions when such pressure or flow data is compared to predicted pressure or flow data, and wherein the pressure or flow data includes differential pressure and a static measure of volume via a manometer.