LIVING BODY COMPONENT ANALYZING METHOD AND LIVING BODY COMPONENT ANALYZING APPARATUS

• US 20130006080A1
• Filed: 09/13/2012
• Published: 01/03/2013
• Est. Priority Date: 03/29/2010
• Status: Abandoned Application

• Current Assignee: Sysmex Corporation
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: OKADA, Seiki, ASAKURA, Yoshihiro, SATO, Toshiyuki, HAGINO, Kei, KOJIMA, Junko
• Application Number:
  US13/614,616
• Publication Number:
  US 20130006080A1
• Time in Patent Office: Days
• US Class Current: 600/362
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157 disposable multilayered or laminated electrodes G01N27/307; details of handling chemical test elements G01N33/4875
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150259 Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150412 Pointed piercing elements, e.g. needles, lancets for piercing the skin blade-like piercing elements A61B5/150442
• CPC Class Codes: A61B 5/150519 Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
• CPC Class Codes: A61B 5/150984 Microneedles or microblades
• CPC Class Codes: A61B 5/15113 Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
• CPC Class Codes: A61B 5/15117 comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
• CPC Class Codes: A61B 5/15186 Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
• CPC Class Codes: A61B 5/1519 comprising driving means, e.g. a spring, for propelling the piercing unit
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

A living body component analyzing method that can accurately analyze a measurement target component even when the subject perspires is provided. A living body component analyzing method for analyzing a component contained in a tissue fluid extracted from the skin of a subject includes: a step of subjecting part of the skin of the subject to a process of facilitating extraction of the tissue fluid; a step of collecting a measurement target component from the skin subjected to the facilitation process; a step of collecting a first auxiliary component from the skin subjected to the facilitation process; a step of collecting a second auxiliary component contained in perspiration from the skin excluding the part subjected to the facilitation process; and a step of analyzing the measurement target component based on the collected measurement target component, the first auxiliary component and the second auxiliary component.

Claims

1. A living body component analyzing method for analyzing a component contained in a tissue fluid extracted from a skin of a subject, including:

a step of subjecting part of a skin of a subject to a process of facilitating extraction of a tissue fluid;

a step of collecting a measurement target component from the skin subjected to the facilitation process;

a step of collecting a first auxiliary component from the skin subjected to the facilitation process;

a step of collecting a second auxiliary component contained in perspiration from the skin excluding the part of the skin subjected to the facilitation process; and

a step of analyzing the measurement target component based on the collected measurement target component, the collected first auxiliary component, and the collected second auxiliary component.

2. The living body component analyzing method according to claim 1, wherein

the first auxiliary component and the second auxiliary component are collected in an identical period.

3. The living body component analyzing method according to claim 1, wherein

the first auxiliary component and the second auxiliary component are collected at an identical arm.

4. The living body component analyzing method according to claim 1, wherein

the step of analyzing includes:

a first measurement step of measuring the collected second auxiliary component to acquire a first measurement value;

a step of comparing the first measurement value with a prescribed threshold value;

a second measurement step of measuring the collected measurement target component to acquire a second measurement value, when the first measurement value is smaller than the prescribed threshold value;

a third measurement step of measuring the collected first auxiliary component to acquire a third measurement value, when the first measurement value is smaller than the prescribed threshold value; and

a step of generating an analysis result including a value relating to an amount of the measurement target component based on the second and third measurement values.

5. The living body component analyzing method according to claim 1, wherein

the step of analyzing includes:

a first measurement step of measuring the collected second auxiliary component to acquire a first measurement value;

a second measurement step of measuring the collected measurement target component to acquire a second measurement value;

a third measurement step of measuring the collected first auxiliary component to acquire a third measurement value; and

a step of generating an analysis result of the measurement target component based on the first to third measurement values.

6. The living body component analyzing method according to claim 5, wherein

the step of generating the analysis result includes:

a step of comparing the first measurement value with the prescribed threshold value; and

a step of generating an analysis result including a value relating to an amount of the measurement target component based on the second and third measurement values and information indicative of the value having low reliability, when the first measurement value is equal to or greater than the prescribed threshold value.

7. The living body component analyzing method according to claim 5, wherein

the step of generating the analysis result includes:

a step of comparing the first measurement value with the prescribed threshold value; and

a step of generating an analysis result including a message expressing that the value relating to the amount of the measurement target component is not to be output, when the first measurement value is equal to or greater than the prescribed threshold value.

8. The living body component analyzing method according to claim 5, wherein

the step of generating the analysis result includes:

a step of comparing the first measurement value with the first threshold value and with a second threshold value, the second threshold value being greater than the first threshold value;

a step of generating an analysis result including a value relating to an amount of the measurement target component based on the second and third measurement values and information indicative of the value having low reliability, when the first measurement value is equal to or greater than the first threshold value and smaller than the second threshold value; and

a step of generating an analysis result including a message expressing that the value relating to the amount of the measurement target component is not to be output, when the first measurement value is equal to or greater than the second threshold value.

9. The living body component analyzing method according to claim 5, wherein

the first measurement value is a value relating to an amount of the second auxiliary component;

the second measurement value is a value relating to an amount of the measurement target component; and

the third measurement value is a value relating to an amount of the first auxiliary component.

10. The living body component analyzing method according to claim 9, wherein

the step of analyzing is a step of generating an analysis result of the measurement target component by correcting the second measurement value by a correction value obtained based on the first measurement value and the third measurement value.

11. The living body component analyzing method according to claim 10, wherein

the correction value is a value obtained by subtracting the first measurement value from the third measurement value.

12. The living body component analyzing method according to claim 11, wherein

each of the values relating to the amount is an extraction amount of each of the auxiliary components per unit time.

13. The living body component analyzing method according to claim 9, wherein

the step of generating the analysis result includes:

a step of comparing the first measurement value with the first threshold value and with a second threshold value, the second threshold value being greater than the first threshold value;

a step of generating an analysis result of the measurement target component by correcting the second measurement value by a correction value based on the first and third measurement values, when the first measurement value is equal to or greater than the first threshold value and smaller than the second threshold value; and

a step of generating an analysis result including a message expressing that the value relating to the amount of the measurement target component is not to be output, when the first measurement value is equal to or greater than the second threshold value.

14. The living body component analyzing method according to claim 1, wherein

the measurement target component is glucose.

15. The living body component analyzing method according to claim 1, wherein

the first auxiliary component and the second auxiliary component are inorganic ions.

16. The living body component analyzing method according to claim 1, wherein

the first auxiliary component and the second auxiliary component are of an identical type.

17. The living body component analyzing method according to claim 15, wherein

the inorganic ions are sodium ions.

18. The living body component analyzing method according to claim 1, wherein

the measurement target component and the first auxiliary component are collected by a collecting material disposed at an application face of a retainer sheet, the application face being capable of being applied to the skin of the subject.

19. The living body component analyzing method according to claim 18, wherein

the collecting material is made of gel.

20. A living body component analyzing apparatus for analyzing a component contained in a tissue fluid extracted from a skin of a subject, comprising:

an acquiring unit that acquires information relating to a measurement target component and a first auxiliary component from a collection member having been disposed for a prescribed time at part of the skin of the subject, the part being subjected to a process of facilitating extraction of the component; and

an analyzing unit that analyzes the measurement target component based on the information relating to the measurement target component and to the first auxiliary component acquired by the acquiring unit, and based on information relating to a second auxiliary component contained in perspiration from the skin excluding the part of the skin subjected to the facilitation process.

21. The living body component analyzing apparatus according to claim 20, further comprising:

a second acquiring unit that acquires information relating to the second auxiliary component.

22. The living body component analyzing apparatus according to claim 20, further comprising:

an information receiving unit that receives the information relating to the second auxiliary component.