Optimized Fc Variants and Methods for their Generation
First Claim
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1. An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution at a position selected from the group consisting of 275, 281, 284, 291 and 299, and wherein numbering is according to the EU index.
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
15 Citations
13 Claims
- 1. An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution at a position selected from the group consisting of 275, 281, 284, 291 and 299, and wherein numbering is according to the EU index.
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2. An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution selected from the group consisting of F275L, F275W, G281D, G281K, G281P, G281Y, V284E, V284L, V284N, V284T, V284Y, P291D, P291E, P291G, P291H, P291I, P291Q, P291T, T299A, T299D, T299E, T299F, T299G, T299H, T299I, T299K, T299L, T299L, T299M, T299N, T299P, T299Q, T299R, T299S, T299V, T299W, T299Y, D265Y/N297D/T299L/I332E, N297D/T299E/I332E, N297D/T299F/I332E, N297D/T299H/I332E, N297D/T299E/I332E, N297D/T299V/I332E, wherein numbering is according to the EU index.
- 3. An antibody or immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid substitution at position selected from the group consisting of 275, 281, 284, 291 and 299, wherein said antibody or immunoadhesin further comprises an amino acid substitution at a position selected from the group consisting of 221, 222, 224, 227, 228, 230, 231, 223, 233, 234, 235, 236, 237, 238, 239, 240, 241, 243, 244, 245, 246, 247, 249, 250, 258, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 278, 280, 281, 283, 285, 286, 288, 290, 291, 293, 294, 295, 296, 297, 298, 299, 300, 302, 313, 317, 318, 320, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335 336 and 428, wherein numbering is according to the EU index.
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13-18. -18. (canceled)
Specification