USE OF 2 ANTI-SPARC ANTIBODIES TO PREDICT RESPONSE TO CHEMOTHERAPY

  • US 20130172261A1
  • Filed: 02/25/2013
  • Published: 07/04/2013
  • Est. Priority Date: 05/28/2009
  • Status: Active Grant
First Claim
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1. A method for predicting the response of a tumor in an animal to a chemotherapeutic regimen comprising:

  • (a) applying a first anti-SPARC antibody to a histologic section of the tumor, wherein the first anti-SPARC antibody preferentially immunostains SPARC in tumor cells;

    (b) applying a second anti-SPARC antibody to the histologic section of (a) or a second histologic section of the tumor, wherein the second anti-SPARC antibody preferentially immunostains SPARC in fibroblasts; and

    (c) predicting a positive response to the chemotherapeutic regimen if the first anti-SPARC antibody and the second anti-SPARC antibody immunostain the histologic section or sections.

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