ANALYTE SENSOR WITH LAG COMPENSATION

• US 20130178727A1
• Filed: 02/08/2013
• Published: 07/11/2013
• Est. Priority Date: 10/23/2007
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary Alan, Doniger, Kenneth J., Budiman, Erwin Satrya
• Granted Patent: US 9,332,934 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: G01N 33/48792 Data management, e.g. communication with processing unit for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades

Abstract

In particular embodiments, methods, devices and systems including calibrating analyte data associated with a monitored analyte level received from an analyte sensor based on a reference measurement, determining a lag time constant associated with the calibrated analyte data, and performing lag correction of the calibrated analyte data based on the determined time lag constant are disclosed.

Claims

1. A computer implemented method, comprising:

calibrating analyte data associated with a monitored analyte level received from an analyte sensor based on a reference measurement;

determining a lag time constant associated with the calibrated analyte data; and

performing lag correction of the calibrated analyte data based on the determined time lag constant.

2. The method of claim 1 including outputting the lag corrected calibrated analyte data.

3. The method of claim 1 wherein the reference measurement includes a blood glucose measurement.

4. The method of claim 1 wherein the reference measurement is obtained within a predetermined time period relative to the monitored analyte level.

5. The method of claim 4 wherein the predetermined time period is less than approximately 30 minutes or greater than approximately 30 minutes.

6. The method of claim 1 wherein calibrating the analyte data includes determining a sensitivity value associated with the analyte sensor.

7. The method of claim 6 wherein the sensitivity value includes a ratio of the analyte data and the corresponding reference measurement.

8. The method of claim 1 wherein the analyte level is glucose level.

9. The method of claim 1 wherein determining the rate of change includes determining a rate of increase or a rate of decrease of the monitored analyte level for a predefined time period.

10. The method of claim 1 further including determining a rate of change of the analyte level monitored by the analyte sensor.

11. The method of claim 10 wherein the rate of change of the analyte level is determined below a predetermined threshold.

12. The method of claim 1 wherein the analyte sensor is configured to measure the analyte level based on coulometry.

13. The method of claim 1 wherein the analyte sensor is configured to measure the analyte level based on amperometry.

14. A method, comprising:

calibrating analyte data associated with a monitored analyte level received from an analyte sensor based on a reference measurement;

determining a time constant component and a time shift component associated with the calibrated analyte data; and

estimating a lag time based on the determined time constant component and the time shift component.

15. The method of claim 14 including performing lag correction of the calibrated analyte data based on the estimated lag time.

16. The method of claim 15 including outputting the lag corrected calibrated analyte data.

17. The method of claim 14 wherein the reference measurement includes a blood glucose measurement.

18. The method of claim 14 wherein the reference measurement is obtained within a predetermined time period relative to the monitored analyte level.

19. The method of claim 14 wherein calibrating the analyte data includes determining a sensitivity value associated with the analyte sensor.

20. An apparatus, comprising:

one or more processors; and

a memory coupled to the one or more processors, the memory for storing instructions which, when executed by the one or more processors, causes the one or more processors to calibrate analyte data associated with a monitored analyte level received from an analyte sensor based on a reference measurement, determine a time constant component and a time shift component associated with the calibrated analyte data, and estimate a lag time based on the determined time constant component and the time shift component.