METHODS AND SYSTEMS FOR LASER TREATMENT USING NON-UNIFORM OUTPUT BEAM

• US 20130178917A1
• Filed: 11/26/2012
• Published: 07/11/2013
• Est. Priority Date: 04/22/2005
• Status: Active Grant

• Current Assignee: Cynosure, LLC (Hologic Incorporated)
• Original Assignee: Cynosure Incorporated
• Inventors: Mirkov, Mirko Georgiev, Sierra, Rafael Armando, Cho, George E.S.
• Granted Patent: US 10,434,324 B2
• Time in Patent Office: Days
• US Class Current: 607/89
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/208 with multiple treatment beams not sharing a common path, e.g. non-axial or parallel
• CPC Class Codes: A61B 2018/2211 Plurality of fibres
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: G02B 5/1885 Arranged as a periodic array

Abstract

Disclosed herein are methods and systems for treatment, such as skin rejuvenation treatment, use non-uniform laser radiation. A high-intensity portion of the laser radiation causes collagen destruction and shrinkage within select portions of the treatment area, while a lower-intensity portion of the radiation causes fibroblast stimulation leading to collagen production across other portions of the treatment area. An output beam from a laser source, such as an Nd:NAG laser, is coupled into an optical system that modifies the beam to provide a large-diameter beam having a nonuniform energy profile, comprised of a plurality of high-intensity zones surrounded by lower-intensity zones within the treatment beam. The higher-intensity zones heat select portions of the tar et tissue to temperatures sufficient for a first treatment (e.g. collagen shrinkage), while the lower-intensity zones provide sufficient energy for a second treatment (e.g. stimulated collagen production).

Claims

1-47. -47. (canceled)

48. A phototherapeutic system, comprising:

an array of at least two laser light sources each laser light source generating an output beam; and

an optical system that modifies the output beam to provide a treatment beam having a non-uniform energy profile, said non-uniform energy profile being comprised of a plurality of regions of relatively high energy per unit area dispersed within a background region of relatively low energy per unit area.

49. The system of claim 48, wherein the treatment beam is configured such that the regions of relatively high energy per unit area deliver sufficient energy to target tissue illuminated by the regions of relatively high energy per unit area to heat the so-illuminated portions of the target tissue to a first temperature T1 and wherein the substantially uniform background region of relatively low energy per unit area delivers sufficient energy to target tissue illuminated by the regions of relatively high energy per unit area to heat the so-illuminated portions of the target to heat the so illuminated portions of the target tissue to a second temperature T2, wherein T2 is less than T1.

50. The system of claim 49, wherein the treatment beam regions of relatively high energy per unit area heat select areas of the target tissue to a first temperature T1 of 35 degrees C. or higher.

51. The system of claim 49, wherein the optical system comprises a diffractive lens array, such that each lens in the array provides a region of relatively high energy per unit area within a substantially uniform background region of relatively low energy per unit area.

52. The system of claim 51, wherein the diffractive lens array comprises between about 100 and about 2000 lenses in the array.

53. The system of claim 51, wherein each lens is between about 150 and 1000 microns in diameter, and wherein the diffractive lens array is between 5 and 10 millimeters in diameter.

54. The system of claim 48, wherein the wavelength of the output beam is between about 1.3 microns and 1.6 microns.

55. The system of claim 54, wherein the wavelength of the output beam is between about 1.40 microns and 1.44 microns.

56. The system of claim 48, wherein the treatment beam at the target tissue area has a diameter between about 5 and 10 mm, and wherein the average fluence of the treatment beam at the target tissue area is less than about 10 J/cm2, and wherein the output beam has a pulse duration of between 0.1 and 100 milliseconds.

57. The system of claim 56, wherein the output beam has a pulse duration of between 20 and 80 milliseconds.

58. The system of claim 56, wherein the average fluence of the treatment beam is less than about 10 J/cm2.

59. The system of claim 48, wherein the optical system comprises a fiber bundle, and wherein the fiber bundle comprises between about 1000 to about 2000 fibers.

60. The system of claim 59, wherein the optical system comprises a focusing lens for coupling the output beam into a proximal end of the fiber bundle, and an optical window between the distal end of the fiber bundle and the target tissue, the optical window permitting the beam emitted from each fiber in the bundle to diverge before it reaches the target skin so that each beam partially overlaps with the beam(s) from adjacent fibers in the bundle.

61. The system of claim 48, wherein the ratio of peak energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 4.5 to 1.

62. The system of claim 48, wherein the ratio of the average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 10 to 1.

63. The system of claim 48, wherein the ratio of average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 50 to 1.

64. The system of claim 48, wherein the ratio of average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 100 to 1.

65. The system of claim 48, wherein the ratio of average energy per unit area in the regions of relatively high energy per unit area to the average energy per unit area in the background region is greater than 150 to 1.

66. A method for treating human tissue, comprising:

generating an output beam from two or more laser light sources;

coupling the output beam into an optical system that modifies the beam to provide a treatment beam having a non-uniform energy profile, said non-uniform energy profile being comprised of regions of relatively high energy per unit area within a background region of relatively low energy per unit area in comparison to the regions of relatively high energy per unit area; and

directing the treatment beam to a target tissue such that the regions of relatively high energy per unit area of the treatment beam illuminate portions of the target tissue and deliver sufficient energy to such portions of the target tissue to heat such portions of the target tissue to a first temperature T1, and wherein the substantially uniform background region of relatively low energy per unit area of the treatment beam illuminates the remaining portion of the target tissue and delivers sufficient energy to such remaining portion of the target tissue to heat the remaining portion of the target tissue to a second temperature T2, wherein T2 is less than T1.

67. The method of claim 66, wherein the treatment beam regions of relatively high energy per unit area heat select portions of the target tissue to a first temperature T1 of 35 degrees C. or higher.

68. The method of claim 66, wherein the laser light source comprises an Nd:

YAG laser or a diode laser.

69. The method of claim 66, wherein the wavelength of the output beam is between about 1.3 microns and 1.6 microns.

70. The method of claim 69, wherein the wavelength of the output beam is between about 1.40 and 1.44 microns.

71. The method of claim 66, wherein the treatment beam at the target tissue area has a diameter between about 5 and 10 mm.

72. The method of claim 71, wherein the average fluence of the treatment beam at the target tissue area is less than about 10 J/cm2.

73. The method of claim 66, wherein the output beam has a pulse duration of between 0.1 and 100 milliseconds.

74. The method of claim 73, wherein the output beam has a pulse duration of between 20 and 80 milliseconds.

75. The method of claim 66, wherein the optical system comprises a fiber bundle.

76. The method of claim 75, wherein the fiber bundle comprises 1000 to 2000 fibers.

77. The method of claim 75, wherein the optical system comprises a focusing lens for coupling the output beam into a proximal end of the fiber bundle, and an optical window between the distal end of the fiber bundle and the target tissue, the optical window permitting the beam emitted from each fiber in the bundle to diverge before it reaches the target skin so that each beam partially overlaps with the beam(s) from adjacent fibers in the bundle.

78. The method of claim 77, wherein the optical window is between 1 and 5 mm thick.

79. The method of claim 75, wherein the average fluence of the treatment beam is less than about 10 J/cm2.

80. The method of claim 75, wherein the optical system comprises a transport fiber that carries the output pulse from the laser source to a handpiece containing the fiber bundle.

81. The method of claim 66, wherein the optical system comprises a diffractive lens array such that each lens in the array provides a region of relatively high energy per unit area, the regions of relatively high energy per unit area within a substantially uniform background region of relatively low energy per unit area in comparison to the regions of relatively high energy per unit area.

82. The method of claim 81, wherein the diffractive lens array comprises about 2000 or less lenses in the array.

83. The method of claim 82, wherein each lens is between about 150 and 1000 microns in diameter.

84. The method of claim 81, wherein the diffractive lens array is between 5 and 10 millimeters in diameter.

85. The method of claim 81, wherein the average fluence of the laser output beam is less than about 10 J/cm2.

86. The method of claim 81, wherein the output beam has a pulse duration between 0.1 and 100 milliseconds.

87. The method of claim 86, wherein the output beam has a pulse duration between 20 and 80 milliseconds.