NOVEL COMPOSITIONS AND METHODS FOR TREATING IgE-MEDIATED DISORDERS
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma.
5 Citations
19 Claims
-
1-13. -13. (canceled)
-
14. An antibody comprising a variable region and an Fc region, wherein said variable region binds membrane anchored IgE, wherein the variable heavy chain of said variable region comprises a vhCDR1 having SEQ ID NO:
- 18, a vhCDR2 having SEQ ID NO;
19, and a vhCDR3 having SEQ ID NO;
20, wherein the variable light chain of said variable region comprises a vlCDR1 having SEQ ID NO;
22, a vlCDR2 having SEQ ID NO;
23, and a vlCDR3 having SEQ ID NO;
24. - View Dependent Claims (15, 16, 17, 18)
- 18, a vhCDR2 having SEQ ID NO;
-
19. A method of making an antibody comprising providing:
-
a) a first nucleic acid encoding a heavy chain, wherein the variable region of said heavy chain comprises a vhCDR1 having SEQ ID NO;
18, a vhCDR2 having SEQ ID NO;
19, and a vhCDR3 having SEQ ID NO;
20;b) a second nucleic acid encoding a light chain, wherein the variable region of said light chain comprises a vlCDR1 having SEQ ID NO;
22, a vlCDR2 having SEQ ID NO;
23, and a vlCDR3 having SEQ ID NO;
24; andc) expressing said nucleic acids under conditions wherein said heavy and light chains are produced.
-
Specification