DIALYSIS IMPLANT AND METHODS OF USE

• US 20130218070A1
• Filed: 05/16/2012
• Published: 08/22/2013
• Est. Priority Date: 08/18/2004
• Status: Active Grant

• Current Assignee: Sequana Medical NV
• Original Assignee: Gregory W. Hall
• Inventors: BURNETT, Daniel R., Hall, Gregory W.
• Granted Patent: US 9,138,523 B2
• Time in Patent Office: Days
• US Class Current: 604/28
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/1676 containing proteins, e.g. albumin
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/282 Operational modes
• CPC Class Codes: A61M 1/285 Catheters therefor
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus

Abstract

A device and methods for treating renal failure are disclosed. One embodiment of the device is an implantable peritoneal dialysis device. When in use, the device can have a semi-permeable reservoir implanted in the peritoneal cavity. The reservoir can receive blood waste and drain through one or more conduits, via a pump, to the biological bladder. Solids and/or a solution benefiting dialysis can be pumped to the reservoir and/or implanted in the peritoneal cavity.

Claims

1-131. -131. (canceled)

132. A peritoneal dialysis system for use with a reservoir configured to infuse dialysate into a peritoneal cavity, the system comprising:

an implantable pump having an internal battery that is inductively chargeable, the implantable pump adapted for fluidic communication with the peritoneal cavity and a bladder;

a drainage conduit adapted for coupling between the peritoneal cavity and the implantable pump;

an exit conduit adapted for coupling between the bladder and the implantable pump, wherein the implantable pump is configured to pump the dialysate from the peritoneal cavity through the drainage conduit into the bladder through the exit conduit; and

an implantable controller associated with the implantable pump, the implantable controller configured to monitor a physiologic parameter, the controller programmed to adjust a rate at which the dialysate is pumped between the peritoneal cavity and the bladder responsive to a value of the monitored physiologic parameter.

133. The system of claim 132, wherein the implantable controller is configured to monitor a difference in pressure between the peritoneal cavity and the bladder.

134. The system of claim 133, wherein the implantable controller includes a clock.

135. The system of claim 134, wherein the implantable controller actuates the implantable pump to meter movement of the dialysate between the peritoneal cavity and the bladder based on an output of the clock.

136. The system of claim 132, further comprising an inductive recharging circuit for recharging the internal battery.

137. The system of claim 132, wherein the drainage conduit comprises a semi-permeable conduit.

138. The system of claim 132, further comprising an anchor attached to the exit conduit, the anchor being configured to anchor an end of the exit conduit within the bladder.

139. The system of claim 132, wherein the monitored physiological parameter comprises pressure, pH, temperature, electrolyte concentration, analyte concentration, or any combination thereof of the peritoneal cavity sensed using a peritoneal sensor.

140. The system of claim 132, wherein the monitored physiological parameter comprises pressure, pH, temperature, electrolyte concentration, analyte concentration, or any combination thereof of the bladder sensed using a bladder sensor.

141. The system of claim 132, wherein the reservoir for use with the system is adapted for implantation.

142. A method of performing peritoneal dialysis on a subject having a peritoneal cavity and a bladder, the method comprising:

implanting a battery powered, inductively rechargeable pump within the subject;

introducing a dialysate into the peritoneal cavity from a reservoir;

pumping the dialysate from the peritoneal cavity into the bladder using the pump;

monitoring a physiologic parameter using an implantable controller associated with the pump; and

adjusting a rate at which the dialysate is pumped between the peritoneal cavity and the bladder responsive to a value of the monitored physiologic parameter.

143. The method of claim 142, further comprising implanting the reservoir in the peritoneal cavity.

144. The method of claim 142, wherein introducing the dialysate comprises introducing the dialysate into the peritoneal cavity from the reservoir through a reservoir conduit.

145. The method of claim 142, wherein introducing the dialysate comprises introducing the dialysate into the peritoneal cavity from the reservoir through a reservoir conduit and a discharge conduit using a second pump,

wherein the reservoir conduit is coupled between the reservoir and the second pump and the discharge conduit is adapted for coupling between the second pump and the peritoneal cavity.

146. The method of claim 142, wherein pumping the dialysate comprises pumping the dialysate from the peritoneal cavity through a drainage conduit into the bladder through an exit conduit,

wherein the drainage conduit is adapted for coupling between the peritoneal cavity and the pump and the exit conduit is adapted for coupling between the pump and the bladder.

147. The method of claim 142, wherein monitoring the physiologic parameter comprises monitoring a condition of the peritoneal cavity sensed by a peritoneal sensor operatively coupled to the implantable controller associated with the pump, and

wherein adjusting the rate comprises adjusting the rate at which the dialysate is pumped between the peritoneal cavity and the bladder responsive the sensed condition of the peritoneal cavity.

148. The method of claim 147, wherein the sensed condition of the peritoneal cavity comprises pressure, pH, temperature, electrolyte concentration, analyte concentration, or any combination thereof of the peritoneal cavity.

149. The method of claim 142, wherein monitoring the physiologic parameter comprises monitoring a condition of the bladder sensed by a bladder sensor operatively coupled to the implantable controller associated with the pump, and

wherein adjusting the rate comprises adjusting the rate at which the dialysate is pumped between the peritoneal cavity and the bladder responsive to the sensed condition of the bladder.

150. The method of claim 149, wherein the sensed condition of the bladder comprises pressure, pH, temperature, electrolyte concentration, analyte concentration, or any combination thereof of the bladder.

151. The method of claim 142, further comprising inductively recharging the battery of the pump.