METHODS AND COMPOSITIONS FOR INCREASING THE ANAEROBIC WORKING CAPACITY IN TISSUES

• US 20130261336A1
• Filed: 05/22/2013
• Published: 10/03/2013
• Est. Priority Date: 08/12/1996
• Status: Active Grant

• Current Assignee: Natural Alternatives International Incorporated (Natural Alternatives LLC)
• Original Assignee: Natural Alternatives International Incorporated (Natural Alternatives LLC)
• Inventors: Harris, Roger, Dunnett, Mark
• Granted Patent: US 8,993,610 B2
• Time in Patent Office: Days
• US Class Current: 562/576
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23P 10/40 free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added A23P10/20, A23P10/30 take precedence
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/175 having the group , >N—C(O)—N=N— or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/197 the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid carnitine A61K31/205
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 38/05 Dipeptides
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 21/06 Anabolic agents androgens A61P5/26
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine and/or creatine.

Claims

1. Use of beta-alanine in manufacturing a human dietary supplement for oral consumption;

wherein the beta-alanine, which is not part of a dipeptide, polypeptide or oligopeptide, is presented in a manufacturing step as a single ingredient or mixing in combination with at least one other ingredient for the manufacture of the human dietary supplement, whereby oral consumption of the human dietary supplement in doses over a period of time increases beta-alanyl histidine levels in muscle tissue sufficient to delay the onset of fatigue in the human.

2. The use of claim 1, wherein a single dose is from about 0.4 g to about 16.0 g of the beta-alanine.

3. The use of claim 1, wherein the period of time is at least 14 days.

4. The use of claim 1, wherein the beta-alanine is present as the single ingredient for the manufacture of the human dietary supplement.

5. The use of claim 1, wherein the beta-alanine is presented in combination with at least one other ingredient for the manufacture of the human dietary supplement.

6. The use of claim 5, wherein the at least one other ingredient comprises creatine.

7. The use of claim 6, wherein the creatine is creatine monohydrate.

8. The use of claim 1, wherein the human dietary supplement is incorporated into a liquid form, solid form, or ingestible suspension.

9. The use of claim 1, wherein the beta-alanine is manufactured in a powder to form the human dietary supplement for oral consumption.