SENSORS WITH THROMBORESISTANT COATING
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Abstract
Embodiments of the present invention relate to analyte sensors comprising a heparin coating, and methods of coating analyte sensors. The heparin can be stably associated with at least a portion of a porous membrane that covers a portion of the analyte sensors. The heparin can be photochemically linked to the coating through the formation of covalent bonds.
9 Citations
40 Claims
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1-24. -24. (canceled)
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25. An analyte sensor, comprising:
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an elongate member; an analyte-responsive indicator disposed along a distal portion of the elongate member, wherein said indicator is capable of generating a signal related to a concentration of analyte; a porous membrane covering at least the indicator along the distal portion of the elongate member; and a coating comprising heparin stably associated with at least a portion of the porous membrane, wherein the heparin is covalently bound to a chemical linking moiety that is covalently bound to the porous membrane. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. An analyte sensor, comprising:
an elongate member; an analyte-responsive indicator disposed along a distal portion of the elongate member, wherein said indicator is capable of generating a signal related to a concentration of analyte; a porous membrane covering at least the indicator along the distal portion of the elongate member; and a film comprising molecules of heparin joined together, the film covalently bound to a chemical linking moiety that is covalently bound to at least a portion of the porous membrane; wherein the molecules of heparin have a sufficient population density to provide a biocompatible effective surface.
Specification