SAMPLE HOLDER WITH A WELL HAVING A WICKING PROMOTER
First Claim
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1. A device for holding a sample, comprising:
- a holder including an upper member attached to a lower member to form a well having a side wall region and a floor, the side wall region extending from a top border to the floor and widening toward the floor at a position intermediate the top border and the floor to create a distinct edge that conceptually divides the well into an upper portion and a lower portion, the well including a protrusion defined by the upper member, the lower member, or both the upper member and the lower member collectively, and adapted to promote wicking of an aqueous sample into the lower portion from the upper portion, the holder defining a channel communicating with the lower portion of the well and with a channel junction that provides a droplet generator.
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Abstract
Sample holding system, including methods and apparatus, including a holder defining a well having a wicking promoter that encourages flow of a sample to the bottom of the well. Methods of making and using the holder are also disclosed.
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Citations
20 Claims
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1. A device for holding a sample, comprising:
a holder including an upper member attached to a lower member to form a well having a side wall region and a floor, the side wall region extending from a top border to the floor and widening toward the floor at a position intermediate the top border and the floor to create a distinct edge that conceptually divides the well into an upper portion and a lower portion, the well including a protrusion defined by the upper member, the lower member, or both the upper member and the lower member collectively, and adapted to promote wicking of an aqueous sample into the lower portion from the upper portion, the holder defining a channel communicating with the lower portion of the well and with a channel junction that provides a droplet generator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A device for holding a sample, comprising:
a holder including an upper member attached to a lower member to form a well having a side wall region and a floor, the side wall region extending from a top border to the floor and widening toward the floor at a position intermediate the top border and the floor to create a distinct edge that conceptually divides the well into an upper portion and a lower portion, the floor defining a protrusion projecting upwardly in the well, the holder defining a channel communicating with the lower portion of the well. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A method of making a device for holding a sample, the method comprising:
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providing an upper member defining at least one through-hole bounded by a side wall region, the side wall region extending from a top border to a bottom border and widening toward the bottom border at a position intermediate the top border and the bottom border to create a distinct edge that conceptually divides the through-hole into an upper portion and a lower portion; and attaching a lower member to an underside of the upper member to create a well bounded laterally by the side wall region and having a floor formed by the lower member, wherein the upper member, the lower member, or both the upper member and the lower member collectively define a protrusion adapted to promote wicking of an aqueous sample into the lower portion from the upper portion. - View Dependent Claims (17, 18, 19, 20)
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Specification