MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.
10 Citations
41 Claims
-
1-27. -27. (canceled)
-
28. A measurement device for estimating glucose concentration comprising:
-
an optical sensor comprising a non-enzymatic, equilibrium fluorescence chemical indicator system disposed along a distal region of an optical fiber, the chemical indicator system comprising a fluorophore operably coupled to a glucose binding moiety, wherein the fluorophore is configured to generate a fluorescent emission signal upon excitation with light, and wherein glucose binding to the glucose binding moiety causes a change in an intensity of the fluorescent emission signal related to the glucose concentration; a pH sensor configured to generate a signal indicative of a pH; and a receiving and processing unit configured to transform the fluorescent emission signal intensity utilizing a first equation for correcting the glucose concentration for changes in pH, wherein the first equation is; - View Dependent Claims (29, 30, 34, 35, 36, 37, 38, 39, 40, 41)
-
-
31. (canceled)
-
32. (canceled)
-
33. (canceled)
Specification