Reservoir Device for Intraocular Drug Delivery
First Claim
Patent Images
1. A sustained release delivery device, the delivery device comprising:
- a refillable reservoir configured to be implanted into a posterior chamber of an eye through a sutureless sclerotomy and formed of a pliable wall configured to contain a therapeutic agent,wherein one or more apertures formed in the pliable wall allow for sustained flow of the therapeutic agent contained in the refillable reservoir through the one or more apertures into the posterior chamber at a rate of delivery, andwherein the pliable wall has a first configuration having a first cross-sectional dimension suitable for insertion of the refillable reservoir through the sclerotomy into the posterior chamber and a second configuration having a second, larger cross-sectional dimension;
an inlet port positioned near a proximal end of the refillable reservoir having an injectable, self-sealing surface; and
an extension projecting outward from the injectable, self-sealing surface having a lower surface configured to abut at least an external portion of the sclera surrounding the sclerotomy such that the device rests on the extension.
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Abstract
A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
30 Citations
20 Claims
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1. A sustained release delivery device, the delivery device comprising:
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a refillable reservoir configured to be implanted into a posterior chamber of an eye through a sutureless sclerotomy and formed of a pliable wall configured to contain a therapeutic agent, wherein one or more apertures formed in the pliable wall allow for sustained flow of the therapeutic agent contained in the refillable reservoir through the one or more apertures into the posterior chamber at a rate of delivery, and wherein the pliable wall has a first configuration having a first cross-sectional dimension suitable for insertion of the refillable reservoir through the sclerotomy into the posterior chamber and a second configuration having a second, larger cross-sectional dimension; an inlet port positioned near a proximal end of the refillable reservoir having an injectable, self-sealing surface; and an extension projecting outward from the injectable, self-sealing surface having a lower surface configured to abut at least an external portion of the sclera surrounding the sclerotomy such that the device rests on the extension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for sustained delivery of a therapeutic agent, the method comprising:
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(1) forming a sclerotomy through to a posterior chamber of an eye, the sclerotomy having a size that requires no sutures for scleral closure; (2) preparing an empty sustained release delivery device for implantation in the eye, the sustained release delivery device comprising; (i) a refillable reservoir formed of a pliable wall configured to contain the therapeutic agent, wherein one or more apertures are formed in the pliable wall; (ii) an inlet port positioned near a proximal end of the refillable reservoir having an injectable, self-sealing surface; and (iii) an extension projecting outward from the injectable, self-sealing surface having a lower surface configured to abut at least an external portion of the sclera surrounding the sclerotomy such that the sustained release delivery device rests on the extension, wherein preparing comprises compressing the pliable wall of the empty sustained release delivery device into a first configuration having a first cross-sectional dimension suitable for insertion of the refillable reservoir through the sclerotomy into the posterior chamber; (3) inserting the compressed, empty reservoir through the sclerotomy into the posterior chamber until the lower surface of the extension abuts the at least an external portion of the sclera surrounding the sclerotomy and the inlet port remains external to the sclerotomy; (4) injecting the therapeutic agent into the reservoir through the inlet port using an injection mechanism; (5) expanding the compressed reservoir into a second configuration having a second cross-sectional dimension that is larger than the first cross-sectional dimension upon injecting the therapeutic agent; and (6) flowing the therapeutic agent from the reservoir through the one or more apertures formed in the pliable wall into the posterior chamber so as to deliver the therapeutic agent at a desired rate of delivery. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification