SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS
First Claim
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1. An implantable continuous analyte sensor, comprising:
- a working electrode; and
a membrane system disposed over at least a portion of the working electrode, the membrane system comprising a first domain and a second domain, the first domain and the second domain each comprising a blend comprising a silicone-containing polymer and a hydrophilic polymer, the first domain having a blend ratio of silicone-containing polymer to hydrophilic polymer that is different than a blend ratio of silicone-containing polymer to hydrophilic polymer of the second domain.
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Abstract
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
22 Citations
17 Claims
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1. An implantable continuous analyte sensor, comprising:
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a working electrode; and a membrane system disposed over at least a portion of the working electrode, the membrane system comprising a first domain and a second domain, the first domain and the second domain each comprising a blend comprising a silicone-containing polymer and a hydrophilic polymer, the first domain having a blend ratio of silicone-containing polymer to hydrophilic polymer that is different than a blend ratio of silicone-containing polymer to hydrophilic polymer of the second domain. - View Dependent Claims (2, 3)
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4. An implantable continuous analyte sensor, comprising:
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a working electrode; and a membrane disposed over the working electrode, the membrane comprising; a first domain configured to have a greater selectivity for reducing permeability therethrough of a first interfering species than a second interfering species; a second domain configured to have a greater selectivity for reducing permeability therethrough of a second interfering species than a first interfering species; and a third domain comprising an enzyme configured to react with an analyte; and wherein the first and second interfering species are molecules that would be electro-reduced or electro-oxidized by the working electrode if they reached an electroactive surface the working electrode. - View Dependent Claims (5, 6, 7)
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8. A method of manufacturing a membrane for use in an analyte sensor, the method comprising:
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mixing a precursor of a silicone elastomer with a poly(ethylene oxide) and poly(propylene oxide) co-polymer; and heating the mixture. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification