IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE THEREOF

• US 20140030277A1
• Filed: 09/26/2013
• Published: 01/30/2014
• Est. Priority Date: 11/06/2006
• Status: Active Grant

• Current Assignee: Boston University, Massachusetts Institute of Technology, The General Hospital Corporation (Mass General Brigham, Inc.), Whitehead Institute
• Original Assignee: Boston University, Massachusetts Institute of Technology, The General Hospital Corporation (Mass General Brigham, Inc.), Whitehead Institute
• Inventors: Rubin-Bejerano, Ifat, Fink, Gerald R., Abeijon, Claudia, Kohane, Daniel S., Fuller, Jason E., Langer, Robert S.
• Granted Patent: US 9,457,047 B2
• Time in Patent Office: Days
• US Class Current: 424/178.1
• CPC Class Codes: A61K 2039/55583 Polysaccharides
• CPC Class Codes: A61K 2039/572 cytotoxic response
• CPC Class Codes: A61K 31/716 Glucans
• CPC Class Codes: A61K 36/064 Saccharomycetales, e.g. baker's yeast
• CPC Class Codes: A61K 36/09 Lichens
• CPC Class Codes: A61K 39/0011 Cancer antigens
• CPC Class Codes: A61K 39/385 Haptens or antigens, bound to carriers
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/61 the organic macromolecular compound being a polysaccharide or a derivative thereof
• CPC Class Codes: A61K 47/6843 the antibody targeting a material from animals or humans
• CPC Class Codes: A61K 47/6921 the form being a particulate, a powder, an adsorbate, a bead or a sphere
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: C08B 37/0024 beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
• CPC Class Codes: C08J 2300/16 Biodegradable polymers
• CPC Class Codes: C08J 2325/06 Polystyrene
• CPC Class Codes: C08J 2367/04 Polyesters derived from hydroxy carboxylic acids, e.g. lactones C08J2367/06 takes precedence
• CPC Class Codes: C08J 2400/16 Biodegradable polymers
• CPC Class Codes: C08J 2405/00 Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
• CPC Class Codes: C08J 3/126 Polymer particles coated by polymer, e.g. core shell structures
• CPC Class Codes: C08J 3/128 : Polymer particles coated by inorganic and non-macromolecular organic compounds

Abstract

This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.

Claims

1. A composition comprising β

-1-6-glucan enriched for O-acetylated groups.

2. The composition of claim 1, wherein said glucan contains at least 25% by weight O-acetylated glucan.

3. The composition of claim 1, wherein said glucan is isolated or derived from a lichen, a fungus or a yeast.

4. The composition of claim 3, wherein said glucan is isolated or derived from Umbilicariaceae.

5. The composition of claim 1, wherein said glucan is genetically engineered, or chemically synthesized or acetylated.

6. The composition of claim 1, further comprising an adjuvant, an antigen, an immuno-modulatory compound, or a combination thereof.

7. The composition of claim 1, wherein said glucan is conjugated to a particle.

8. A method of modulating an immune response in a subject, said method comprising administering to said subject a composition comprising β

-1-6-glucan optionally enriched for O-acetylated groups.

9. The method of claim 8, wherein said glucan contains at least 25% by weight O-acetylated glucan.

10. The method of claim 8, wherein said glucan is isolated or derived from a lichen or a fungus, wherein said fungus is optionally a yeast.

11. The method of claim 10, wherein said glucan is isolated or derived from Umbilicariaceae.

12. The method of claim 8, wherein said composition further comprises an adjuvant, an antigen, an immuno-modulatory compound, or a combination thereof.

13. The method of claim 8, wherein said glucan is conjugated to a particle.

14. The method of claim 8, wherein modulating said immune response comprises stimulating said immune response.

15. The method of claim 8, wherein said immune response is an antigen-specific response.

16. The method of claim 8, wherein said composition further comprises a chemotherapeutic compound.

17. The method of claim 8, wherein said immune response is complement-dependent.

18. The method of claim 8, wherein said immune response is directed against an infectious agent, a cancer, a preneoplastic lesion or a combination thereof.

19. The method of claim 18, wherein said infectious agent causes sepsis.

20. The method of claim 18, wherein said infectious agent is a parasite, helminth, virus or bacteria.

21-150. -150. (canceled)