Methods of Analyte Monitoring, and Devices and Systems Related Thereto

• US 20140095081A1
• Filed: 09/27/2013
• Published: 04/03/2014
• Est. Priority Date: 09/28/2012
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Doniger, Kenneth J., Hayter, Gary A., McGarraugh, Geoffrey V., Springer, Scott A.
• Granted Patent: US 10,108,781 B2
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Methods, devices, and systems are provided that determine analyte trends according to different methods depending on whether a change-resistant state is active or not active. The method used when the change-resistant state is activated provides for different requirements for a resulting analyte trend to transition between states (e.g., level to non-level). Furthermore, in some aspects, methods, devices, and systems of selecting or modifying a response rate of an analyte monitoring device for an individual user are provided. User instructions for selecting or modifying a response rate of the device or system is received externally via a user interface or communication channel. The response rate of the analyte monitoring device or system is then selected or modified to the first response rate, and the device or system operated with the first response rate.

Claims

1. A method of determining analyte trends, comprising:

receiving in vivo derived analyte measurements;

calculating, with a processor, initial trends as level or non-level based on a rate-of-change for a current analyte measurement and at least one past analyte measurement, wherein an initial trend is level when the rate-of-change is zero or within a predetermined tolerance range for zero; and

determining, with the processor, whether final trends for display on a user interface are level or non-level, wherein the final trend determinations are based on the initial trend calculations and whether a change-resistant state is active;

wherein when the change-resistant state is active, a minimum threshold of change is required between the current analyte measurement and a past analyte measurement selected as a reference in order for a final trend to transition from level to non-level;

wherein a change-resistant state is activated each time a final trend is determined to be level and deactivated each time a final trend is determined to be non-level; and

wherein the minimum threshold of change varies depending on the value of the current analyte measurement.

2. The method of claim 1, wherein when the change-resistant state is not active, the final trend is determined to be the same as the initial trend;

wherein when the change-resistant state is active and the initial trend is calculated to be level, the final trend is determined to be level; and

wherein when the change-resistant state is active and the initial trend is calculated to be non-level, the minimum threshold of change is implemented to determine whether the final trend is non-level.

3. The method of claim 1, comprising displaying the final trends on a display of a user interface of an analyte monitoring device.

4. The method of claim 1, wherein the analyte is glucose or a ketone body.

5. An analyte monitoring device, comprising:

a user interface for displaying analyte trends;

a processor operably coupled to the user interface; and

memory operably coupled to the processor, wherein the memory includes instructions stored therein that, when executed by the processor, cause the processor to;

receive in vivo derived analyte measurements;

calculate initial trends as level or non-level based on a rate-of-change for a current analyte measurement and at least one past analyte measurement, wherein an initial trend is level when the rate-of-change is zero or within a predetermined tolerance range for zero; and

determine whether final trends for display on the user interface are level or non-level, wherein the final trend determinations are based on the initial trend calculations and whether a change-resistant state is active;

wherein when the change-resistant state is active, a minimum threshold of change is required between the current analyte measurement and a past analyte measurement selected as a reference in order for a final trend to transition from level to non-level;

wherein a change-resistant state is activated each time a final trend is determined to be level and deactivated each time a final trend is determined to be non-level; and

wherein the minimum threshold of change varies depending on the value of the current analyte measurement.

6. The analyte monitoring device of claim 5, wherein when the change-resistant state is not active, the final trend is determined to be the same as the initial trend;

wherein when the change-resistant state is active and the initial trend is calculated to be level, the final trend is determined to be level; and

wherein when the change-resistant state is active and the initial trend is calculated to be non-level, the minimum threshold of change is implemented to determine whether the final trend is non-level.

7. The analyte monitoring device of claim 5, wherein the instructions include instructions, which when executed by the processor, cause the processor to display the final trends on the user interface of the analyte monitoring device.

8. The analyte monitoring device of claim 5, wherein the analyte is glucose or a ketone body.

9. An analyte monitoring system, comprising:

an in vivo positionable analyte sensor;

sensor electronics coupled to the in vivo positionable analyte sensor comprising;

a first processor; and

first memory operably coupled to the first processor; and

a analyte monitoring device configured to communicate with the sensor electronics unit, the analyte monitoring device comprising;

a user interface for displaying analyte trends;

a second processor operably coupled to the user interface; and

second memory operably coupled to the second processor;

wherein at least one of the first memory and second memory includes instructions stored therein that, when executed by at least one of the first and second processors, cause the at least one first and second processors to;

receive in vivo derived analyte measurements;

calculate initial trends as level or non-level based on a rate-of-change for a current analyte measurement and at least one past analyte measurement, wherein an initial trend is level when the rate-of-change is zero or within a predetermined tolerance range for zero; and

determine whether final trends for display on the user interface are level or non-level, wherein the final trend determinations are based on the initial trend calculations and whether a change-resistant state is active;

wherein when the change-resistant state is active, a minimum threshold of change is required between the current analyte measurement and a past analyte measurement selected as a reference in order for a final trend to transition from level to non-level;

wherein a change-resistant state is activated each time a final trend is determined to be level and deactivated each time a final trend is determined to be non-level; and

wherein the minimum threshold of change varies depending on the value of the current analyte measurement.

10. The analyte monitoring system of claim 9, wherein when the change-resistant state is not active, the final trend is determined to be the same as the initial trend;

wherein when the change-resistant state is active and the initial trend is calculated to be level, the final trend is determined to be level; and

wherein when the change-resistant state is active and the initial trend is calculated to be non-level, the minimum threshold of change is implemented to determine whether the final trend is non-level.

11. The analyte monitoring system of claim 9, wherein the instructions include instructions, which when executed by at least one of the first and second processors, cause the at least one first and second processors to display the final trends on the user interface of the analyte monitoring device.

12. The analyte monitoring system of claim 9, wherein the analyte is glucose or a ketone body.

13. A method of selecting or modifying a response rate of an analyte monitoring device for an individual user, the method comprising:

receiving, with a processor, user instructions for selecting a first response rate tailored to a first user, wherein the instructions are received externally via a user interface or a communication channel of the analyte monitoring device;

selecting or modifying, with the processor, the response rate of the analyte monitoring device to the first response rate; and

operating the analyte monitoring device with the first response rate;

wherein the first response rate comprises one or more of the following;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data; and

a time delay for a warning or alarm.

14. The method of claim 13, wherein the first response rate is tailored to physiological characteristics of the first user, the physiological characteristics comprising characteristics of the user'"'"'s response to medicine or analyte absorption.

15. The method of claim 13, wherein the response rate of the analyte monitoring device is increased, with the processor, by performance of one or more of the following:

increasing the frequency at which the data is displayed;

decreasing the amount of averaging or smoothing of the analyte measurement data; and

decreasing the time delay for the warning or alarm.

16. The method of claim 13, wherein the response rate of the analyte monitoring device is decreased, with the processor, by performance of one or more of the following:

decreasing the frequency at which the data is displayed;

increasing the amount of averaging or smoothing of the analyte measurement data; and

increasing the time delay for the warning or alarm.

17. The method of claim 13, comprising:

receiving, with the processor, instructions for selecting a second response rate tailored to the first user, wherein the instructions are received externally via the user interface or the communication channel of the analyte monitoring device, and wherein the first response rate and second response rate are associated with different times of treatment;

selecting or modifying, with the processor, the response rate of the analyte monitoring device to the first response rate at the corresponding times of treatment associated with the first response rate;

operating the analyte monitoring device with the first response rate at the corresponding times of treatment associated with the first response rate;

selecting or modifying, with the processor, the response rate of the analyte monitoring device to the second response rate at the corresponding times of treatment associated with the second response rate; and

operating the analyte monitoring device with the second response rate at the corresponding times of treatment associated with the second response rate;

wherein the second response rate comprises;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data, and/or

one or more time delays for a warning or alarm.

18. The method of claim 13, comprising:

receiving, with the processor, instructions for selecting a third response rate tailored to a second user, wherein the instructions are received externally via the user interface or the communication channel of the analyte monitoring device;

selecting or modifying, with the processor, the response rate of the analyte monitoring device to the third response rate; and

operating the analyte monitoring device with the third response rate;

wherein the third response rate comprises;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data, and/or

one or more time delays for a warning or alarm.

19. The method of claim 13, wherein the analyte is glucose.

20. An analyte monitoring device, comprising:

a processor; and

memory operably coupled to the processor, wherein the memory includes instructions stored therein to select or modify a response rate of an analyte monitoring device for an individual user, wherein the instructions, when executed by the processor, cause the processor to;

receive user instructions for selecting a first response rate tailored to a first user, wherein the user instructions are received externally via a user interface or a communication channel of the analyte monitoring device;

select or modify the response rate of the analyte monitoring device to the first response rate; and

operate the analyte monitoring device with the first response rate;

wherein the first response rate comprises one or more of the following;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data; and

a time delay for a warning or alarm.

21. The analyte monitoring device of claim 20, wherein the first response rate is tailored to physiological characteristics of the first user, the physiological characteristics comprising characteristics of the user'"'"'s response to medicine or analyte absorption.

22. The analyte monitoring device of claim 20, wherein the response rate of the analyte monitoring device is increased by performance of one or more of the following:

increasing the frequency at which the data is displayed;

decreasing the amount of averaging or smoothing of the analyte measurement data; and

decreasing the time delay for the warning or alarm.

23. The analyte monitoring device of claim 20, wherein the response rate of the analyte monitoring device is decreased by performance of one or more of the following:

decreasing the frequency at which the data is displayed;

increasing the amount of averaging or smoothing of the analyte measurement data; and

increasing the time delay for the warning or alarm.

24. The analyte monitoring device of claim 20, wherein the instructions include instructions, which when executed by the processor, cause the processor to:

receive instructions for selecting a second response rate tailored to the first user, wherein the instructions are received externally via the user interface or the communication channel of the analyte monitoring device, and wherein the first response rate and second response rate are associated with different times of treatment;

select or modify the response rate of the analyte monitoring device to the first response rate at the corresponding times of treatment associated with the first response rate;

operate the analyte monitoring device with the first response rate at the corresponding times of treatment associated with the first response rate;

select or modify the response rate of the analyte monitoring device to the second response rate at the corresponding times of treatment associated with the second response rate; and

operate the analyte monitoring device with the second response rate at the corresponding times of treatment associated with the second response rate;

wherein the second response rate comprises;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data, and/or

one or more time delays for a warning or alarm.

25. The analyte monitoring device of claim 20, wherein the instructions include instructions, which when executed by the processor, cause the processor to:

receive user instructions for selecting a third response rate tailored to a second user, wherein the user instructions are received externally via the user interface or the communication channel of the analyte monitoring device;

select or modify the response rate of the analyte monitoring device to the third response rate; and

operate the analyte monitoring device with the third response rate;

wherein the third response rate comprises;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data, and/or

one or more time delays for a warning or alarm.

26. The analyte monitoring device of claim 20, wherein the analyte is glucose.

27. An analyte monitoring system, comprising:

a sensor electronics unit, comprising;

a first processor and first memory operably coupled to the first processor;

an in vivo analyte sensor operably coupled to the first processor; and

a receiver configured to communicate with the sensor electronics unit, the receiver comprising;

a second processor and second memory operably coupled to the second processor;

wherein at least one of the first memory and second memory includes instructions stored therein to select or modify a response rate of an analyte monitoring device for an individual user, wherein the instructions, when executed by at least one of the first and second processors, cause the at least one first and second processor to;

receive user instructions for selecting a first response rate tailored to a first user, wherein the user instructions are received externally via a user interface or a communication channel of the analyte monitoring system;

select or modify the response rate of the analyte monitoring system to the first response rate; and

operate the analyte monitoring system with the first response rate;

wherein the first response rate comprises one or more of the following;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data; and

a time delay for a warning or alarm.

28. The analyte monitoring system of claim 27, wherein the first response rate is tailored to physiological characteristics of the first user, the physiological characteristics comprising characteristics of the user'"'"'s response to medicine or analyte absorption.

29. The analyte monitoring system of claim 27, wherein the response rate of the analyte monitoring system is increased by performance of one or more of the following:

increasing the frequency at which the data is displayed;

decreasing the amount of averaging or smoothing of the analyte measurement data; and

decreasing the time delay for the warning or alarm.

30. The analyte monitoring system of claim 27, wherein the response rate of the analyte monitoring system is decreased by performance of one or more of the following:

decreasing the frequency at which the data is displayed;

increasing the amount of averaging or smoothing of the analyte measurement data; and

increasing the time delay for the warning or alarm.

31. The analyte monitoring system of claim 27, wherein the instructions include instructions, when executed by at least one of the first and second processors, cause the at least one first and second processor to:

receive user instructions for selecting a second response rate tailored to the first user, wherein the user instructions are received externally via the user interface or the communication channel of the analyte monitoring system, and wherein the first response rate and second response rate are associated with different times of treatment;

select or modify the response rate of the analyte monitoring system to the first response rate at the corresponding times of treatment associated with the first response rate;

operate the analyte monitoring system with the first response rate at the corresponding times of treatment associated with the first response rate;

select or modify the response rate of the analyte monitoring system to the second response rate at the corresponding times of treatment associated with the second response rate; and

operate the analyte monitoring system with the second response rate at the corresponding times of treatment associated with the second response rate;

wherein the second response rate comprises;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data, and/or

one or more time delays for a warning or alarm.

32. The analyte monitoring system of claim 27, wherein the instructions include instructions, which when executed by at least one of the first and second processors, cause the at least one first and second processor to:

receive user instructions for selecting a third response rate tailored to a second user, wherein the user instructions are received externally via the user interface or the communication channel of the analyte monitoring system;

select or modify the response rate of the analyte monitoring system to the third response rate; and

operate the analyte monitoring system with the third response rate;

wherein the third response rate comprises;

a frequency at which data is displayed;

an amount of averaging or smoothing of analyte measurement data, and/or

one or more time delays for a warning or alarm.

33. The analyte monitoring system of claim 27, wherein the analyte is glucose.