INJECTABLE AND MOLDABLE BONE SUBSTITUTE MATERIALS
First Claim
1. A composite osteoimplant comprising:
- a plurality of particles comprising an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and
a polymer with which the plurality of particles has been combined;
wherein the composite is moldable or flowable; and
wherein the composite becomes set upon exposure to suitable conditions for setting the composite.
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Abstract
An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
7 Citations
21 Claims
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1. A composite osteoimplant comprising:
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a plurality of particles comprising an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer with which the plurality of particles has been combined; wherein the composite is moldable or flowable; and wherein the composite becomes set upon exposure to suitable conditions for setting the composite. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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2. A composite osteoimplant comprising:
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a plurality of bone-derived particles; and a polymer with which the particles have been combined; wherein the composite has an initial phase and a set phase;
wherein the set phase is more resistant to mechanical deformation relative to the initial phase.
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3. A composite osteoimplant comprising:
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a plurality of bone-derived particles; and a polymer with which the particles have been combined; wherein the composite has a first phase and a second phase;
wherein the second phase is more resistant to mechanical deformation relative to the first phase. - View Dependent Claims (5, 6)
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4. A composite osteoimplant comprising:
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a plurality of bone-derived particles; and a polymer with which the particles have been combined; wherein the composite has a first phase and a second phase;
wherein the first phase is more moldable, flowable, or injectable relative to the second phase.
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21-160. -160. (canceled)
Specification