METHODS AND DEVICES FOR COMPOUND DELIVERY

• US 20140144429A1
• Filed: 01/30/2014
• Published: 05/29/2014
• Est. Priority Date: 11/28/2012
• Status: Active Grant

• Current Assignee: Fontem Ventures BV (Imperial Tobacco Group PLC)
• Original Assignee: e-Nicotine Technology, Inc (Imperial Tobacco Group PLC)
• Inventors: Wensley, Martin, Hufford, Michael, Lloyd, Peter, Williams, Jeffrey
• Granted Patent: US 10,034,988 B2
• Time in Patent Office: Days
• US Class Current: 128/200.14
• CPC Class Codes: A61M 11/041 using heaters
• CPC Class Codes: A61M 15/06 Inhaling appliances shaped like cigars, cigarettes or pipes
• CPC Class Codes: A61M 16/0066 Blowers or centrifugal pumps
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws

Abstract

Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine cessation.

Claims

1. A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation comprising a pharmaceutically active agent, the device comprising:

a. a reservoir comprising the liquid formulation comprising the pharmaceutically active agent; and

b. a passageway comprising a heater element, an inlet, and an outlet, wherein the heater element is disposed in the passageway between the inlet and the outlet, and wherein the reservoir is in fluid communication with the heater element, wherein the passageway is configured to produce a condensation aerosol in the device, wherein the condensation aerosol has a mass median aerodynamic diameter (MMAD) of from about 1 μ

M to about 5 μ

m.

2. The device of claim 1, wherein the heater element comprises a wick element and a coil.

3. The device of claim 2, wherein the wick element and coil are formed from the same rod.

4. The device of claim 2, wherein the coil is wrapped around the wick element.

5. The device of claim 1, further comprising a baffle disposed in the passageway between the outlet and the heater element, wherein the baffle inhibits flow of particles having an MMAD of greater than 5 μ

m.

6. The device of claim 1, further comprising a tube disposed within the passageway and connected to the reservoir, wherein the tube is configured to deliver the liquid formulation comprising the pharmaceutically active agent to the heater element.

7. The device of claim 1, wherein a flow rate of a gas through device is capable of delivering the condensation aerosol of the liquid formulation comprising the pharmaceutically active agent to a deep lung of a user of the device.

8. The device of claim 7, wherein the flow rate of gas through the device that is capable of delivering the condensation aerosol of the liquid formulation comprising the pharmaceutically active agent to a deep lung of a user of the device is from about 20 liters per minute (LPM) to about 80 LPM at a vacuum of about 1 to about 15 inches of water.

9. The device of claim 1, wherein the device permits a flow resistance of from about 0.05 to about 0.15 sqrt (cm-H₂O)/LPM.

10. The device of claim 1, wherein the heater element is capable of vaporizing the liquid formulation comprising the pharmaceutically active agent when the liquid formulation comprising the pharmaceutically active agent is delivered to the heater element, wherein the vaporized liquid formulation comprising the pharmaceutically active agent is condensed into aerosol particles in the device.

13. The device of claim 1, wherein the programmable controller is connected to one or more electronic devices.

14. The device of claim 13, wherein the one or more electronic devices comprise a computer, a smartphone, or a mobile phone.

11. A condensation aerosol generating device for generating a condensation aerosol comprising a pharmaceutically active agent, the device comprising:

a. a housing comprising a heater element for vaporizing a liquid formulation comprising the pharmaceutically active agent, wherein the heater element is located between an outlet and an inlet in the housing;

b. a reservoir comprising the liquid formulation, wherein the reservoir is in fluid communication with the heater element;

c. a passageway for condensing a vaporized liquid formulation comprising the pharmaceutically active agent, wherein the passageway is in fluid communication with the heater element; and

d. a programmable controller.

12. The device of claim 11, wherein the programmable controller comprises a non-transitory computer readable medium, wherein the non-transitory computer readable medium comprises one or more algorithms for regulating dosage of the pharmaceutically active agent, frequency of administration of the pharmaceutically active agent, or a delivery schedule of the pharmaceutically active agent.

15. The device of claim 11, wherein the heater element comprises a wick element and a coil.

16. The device of claim 15, wherein the wick element and coil are formed from the same rod.

17. The device of claim 15, wherein the coil is wrapped around the wick element.

18. The device of claim 11, wherein the device produces condensation aerosol particles having a mass median aerodynamic diameter (MMAD) of from about 1 μ

m to about 5 μ

m.

19. The device of claim 11, wherein a flow rate of gas in the device is capable of delivering the condensation aerosol of the liquid formulation comprising the pharmaceutically active agent to a deep lung of a user, wherein the flow rate is from about 20 LPM to about 80 LPM at a vacuum of about 1 to about 15 inches of water.

20. The device of claim 11, wherein the device permits a flow resistance of from about 0.05 to about 0.15 sqrt (cm-H₂O)/LPM.

21. A method for administering a pharmaceutically active agent to a deep lung of a subject, the method comprising:

a. generating a condensation aerosol comprising a pharmaceutically active agent, wherein the generating comprises vaporizing a liquid formulation comprising the pharmaceutically active agent using a heater element, wherein the heater element is disposed in a passageway of a condensation aerosol generating device, wherein the condensation aerosol has an MMAD of from about 1 μ

M to about 5 μ

m; and

b. flowing a gas through the condensation aerosol generating device at a flow rate effective to allow delivery of the condensation aerosol comprising the pharmaceutically active agent to a deep lung of a subject using the device, thereby administering the pharmaceutically active agent to the deep lung of the subject.

22. The method of claim 21, wherein the flowing comprises flowing a gas at a rate of about 20 LPM to about 80 LPM at a vacuum of about 1 to about 15 inches of water.

23. The method of claim 21, wherein the condensation aerosol generating device permits a flow resistance of from about 0.05 to about 0.15 sqrt (cm-H₂O)/LPM.

24. The method of claim 21, wherein the condensation aerosol is formed at a flow rate of about 1 LPM to about 10 LPM past the heater element under a vacuum of between about 1 to about 15 inches of water.

25. The method of claim 21, wherein the heater element comprises a wick element and a coil.

26. The method of claim 25, wherein the wick element comprises an electrically resistive material.

27. The method of claim 26, wherein the wick element and coil are formed from the same rod.

28. The method of claim 21, wherein the condensation aerosol generating device comprises a programmable controller.

29. The method of claim 28, wherein the programmable controller comprises a non-transitory computer readable medium, wherein the non-transitory computer readable medium comprises one or more algorithms for regulating dosage of the pharmaceutically active agent, frequency of administration of the pharmaceutically active agent, or a delivery schedule of the pharmaceutically active agent.

30. The method of claim 29, wherein the subject is a human.