Systems for Comprehensive Fourier Domain Optical Coherence Tomography (FDOCT) and Related Methods

• US 20140160431A1
• Filed: 01/06/2014
• Published: 06/12/2014
• Est. Priority Date: 10/23/2009
• Status: Active Grant

• Current Assignee: Bioptigen, Inc. (Danaher Corporation)
• Original Assignee: Bioptigen, Inc. (Danaher Corporation)
• Inventors: Izatt, Joseph A., Buckland, Eric L., Bower, Bradley A., Hart, Robert H.
• Granted Patent: US 9,259,150 B2
• Time in Patent Office: Days
• US Class Current: 351/206
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 3/117 for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
• CPC Class Codes: A61B 3/1225 using coherent radiation
• CPC Class Codes: G01B 9/0201 using temporal phase variation
• CPC Class Codes: G01B 9/02078 Caused by ambiguity
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.

Claims

1. (canceled)

2. An optical coherence tomography system for imaging a whole eye, the system comprising:

a sample arm including focal optics configured to switch between at least two scanning modes,

wherein the at least two scanning modes comprise an anterior segment scanning mode and a retinal scanning mode;

wherein the sample arm of the system in retinal scanning mode comprises a collimator, a two-axis scanning mirror assembly, and a scan lens assembly, an objective lens; and

wherein the focal optics of the sample arm are configured to reposition at least one movable lens to change an optical coherence tomography (OCT) scan beam from a collimated beam for imaging an emmetropic eye to one of a diverging beam for imaging a myopic eye and a converging beam for imaging a hyperopic eye;

a mechanical means for modifying components within an optical pathway of the sample arm to switch the scanning mode between the retinal scanning mode and the anterior segment scanning mode; and

a reference arm coupled to the sample arm and comprising a means for discrete switching between two path delays in coordination with switching between the at least two scanning modes,

wherein a first path delay is configured to match an optical path length of the OCT scan beam in the retinal scanning mode and a second path delay is configured to match an optical path length of the OCT scan beam in anterior segment scanning mode.

3. The system of claim 2, wherein the focal optics of the sample arm are further configured to reposition the at least one movable lens using a mechanical means for insertion of an additional lens assembly into the optical pathway of the sample arm immediately proximal or immediately distal to the collimator to change the system from the retinal scanning mode to anterior segment scanning mode.

4. The system of claim 2:

wherein the sample arm of the system in the anterior segment scanning mode comprises a collimating lens, two two-axis scanning mirror assemblies, a scan lens, an objective lens and a curved mirror placed a focal length (f) away from a first of the two two-axis scanning mirror assemblies,

wherein a second of the two two-axis scanning mirror assemblies is configured to direct re-directed collimated light in a triangular pattern towards the curved mirror causing the optical path length of the system to be longer in the anterior segment scanning mode than in the retinal scanning mode.

5. The system of claim 2:

wherein the sample arm of the system in the anterior segment scanning mode comprises a collimating lens, a two-axis scanning mirror assembly, a scan lens, an objective lens, a flat mirror and a concave mirror placed a focal length (f) away from the two-axis scanning mirror assembly, wherein light incident on the two-dimensional scanner pair is deviated such that the an incident collimated beam is directed into a separate path consisting of the flat mirror and the concave mirror.

6. The system of claim 2, wherein the means for discrete switching a reference delay comprises a rapid mechanical switch configured to block all but a identified reference delay associated with a corresponding one of the at least two scanning modes.