DEVICE FOR CONTROLLING A PISTON PUMP UNIT FOR LIQUID CHROMATOGRAPHY
First Claim
1. A device for controlling a piston pump unit for liquid chromatography comprising:
- (a) at least two phase-offset cyclically working piston-cylinder units, which produce a predefined flow of a liquid medium to be delivered at an outlet port, wherein a system pressure results at the outlet port,(b) wherein, in a pre-compression phase of one cycle of at least one of the piston-cylinder units, an at least partially adiabatic compression of the medium from a starting pressure to the system pressure occurs, and wherein, in a following delivery phase, in which the flow is also determined at least by the piston-cylinder unit, the medium, which is adiabatically heated during the pre-compression phase, is cooled during a transition phase of the delivery phase, and(c) a control unit, which activates a drive device for the at least two piston-cylinder units with respect to the speed, at which the pistons of the piston-cylinder units are moved,(d) the control unit detects a pressure of the medium in at least one of the piston-cylinder units during the pre-compression phase or during a part of the delivery phase in which a cooling of the adiabatically heated medium occurs,(e) the control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.
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Accused Products
Abstract
A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.
11 Citations
29 Claims
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1. A device for controlling a piston pump unit for liquid chromatography comprising:
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(a) at least two phase-offset cyclically working piston-cylinder units, which produce a predefined flow of a liquid medium to be delivered at an outlet port, wherein a system pressure results at the outlet port, (b) wherein, in a pre-compression phase of one cycle of at least one of the piston-cylinder units, an at least partially adiabatic compression of the medium from a starting pressure to the system pressure occurs, and wherein, in a following delivery phase, in which the flow is also determined at least by the piston-cylinder unit, the medium, which is adiabatically heated during the pre-compression phase, is cooled during a transition phase of the delivery phase, and (c) a control unit, which activates a drive device for the at least two piston-cylinder units with respect to the speed, at which the pistons of the piston-cylinder units are moved, (d) the control unit detects a pressure of the medium in at least one of the piston-cylinder units during the pre-compression phase or during a part of the delivery phase in which a cooling of the adiabatically heated medium occurs, (e) the control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. (canceled)
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16. (canceled)
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17. A method to control a piston pump for liquid chromatography, the piston pump including at least two phase-offset cyclically working piston-cylinder units, which produce a predefined flow of a liquid medium to be delivered at an outlet port, wherein a constant system pressure results at the outlet port, the method comprising:
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in a pre-compression phase of one cycle of at least one of the piston-cylinder units, compressing a piston in the piston-cylinder unit; measuring a first pressure at a first time and a second pressure at a second time during the pre-compression phase in which an adiabatic heating effect is negligible in the piston-cylinder unit; extrapolating the first pressure at the first time and the second pressure at the second time to determine a calculated time in which the pressure of the piston-cylinder unit will be at the constant system pressure; determining a detected time in which the pressure of the piston-cylinder unit is measured with a pressure sensor to be at the constant system pressure; calculating a time difference based on the calculated time and the detected time; and calculating a first correction amplitude of the piston speed for at least one piston-cylinder unit based on the time difference. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method to control a piston pump for liquid chromatography, the piston pump including at least two phase-offset cyclically working piston-cylinder units, which produce a predefined flow of a liquid medium to be delivered at an outlet port, the method comprising:
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in a first pre-compression phase of one cycle of at least one of the piston-cylinder units, compressing a piston in the piston-cylinder unit; measuring a pressure profile at the outlet port during the pre-compression phase, wherein a system pressure at the outlet port increases linearly; opening an outlet valve on the piston-cylinder unit to begin a first delivery phase of the liquid medium; linearly extrapolating the pressure profile at the beginning of the first delivery phase; calculating a first pressure difference between the linearly extrapolated pressure profile at the beginning of the first delivery phase and a measured system pressure during the first delivery phase; and calculating a first correction amplitude of the piston speed based on the first pressure difference. - View Dependent Claims (28, 29)
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Specification