SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER
First Claim
1. A method of forming a nanopore in a lipid bilayer, comprising:
- depositing a nanopore forming solution over a lipid bilayer, the nanopore forming solution having a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed in the lipid bilayer un-stimulated; and
initiating formation of a nanopore in the lipid bilayer by a processor, comprising applying an agitation stimulus level to the lipid bilayer.
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Abstract
A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.
6 Citations
24 Claims
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1. A method of forming a nanopore in a lipid bilayer, comprising:
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depositing a nanopore forming solution over a lipid bilayer, the nanopore forming solution having a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed in the lipid bilayer un-stimulated; and initiating formation of a nanopore in the lipid bilayer by a processor, comprising applying an agitation stimulus level to the lipid bilayer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A system for forming a nanopore in a lipid bilayer, comprising:
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a chamber containing a nanopore forming solution, wherein the nanopore forming solution is deposited over a lipid bilayer, the nanopore forming solution having a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed in the lipid bilayer un-stimulated; and a processor programmed to control a source to initiate formation of a nanopore in the lipid bilayer, wherein initiating formation of a nanopore comprises applying an agitation stimulus level to the lipid bilayer. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification