DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING
4 Assignments
0 Petitions
Accused Products
Abstract
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.
3 Citations
23 Claims
-
1-11. -11. (canceled)
-
12. A method for producing a resorbable, flexible bone graft scaffold material comprising:
-
forming a plurality of resorbable fibers; interlinking the plurality resorbable fibers to define a fabric having a plurality of open pores; and filling at least some of the open pores with bioactive, resorbable ceramic microspheres; wherein the fibers are characterized by fiber diameters substantially ranging from about 5 nanometers to about 10 micrometers; and wherein the microspheres are characterized by diameters ranging up to about 3 millimeters. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. A method for regenerating tissue, with a resorbable, flexible bone graft scaffold material comprising:
-
interconnecting a plurality resorbable fibers to define a flexible scaffolding material having a plurality of open pores; and filling at least some of the open pores with bioactive, resorbable ceramic microspheres to define a tissue regrowth scaffolding material; filing a wound with tissue regrowth scaffolding material; wherein the interconnected fibers are able to move relative to one another; wherein the respective fibers have respective fiber diameters between about 5 nanometers and about 10 micrometers; and wherein the microspheres have respective sphere diameters from about 1 nanometer to about 3 millimeters.
-
-
23. A method making and using a resorbable, flexible bone graft scaffold material comprising:
-
forming a plurality of resorbable fibers; interlinking the plurality resorbable fibers to define a fabric having a plurality of open pores; and filling at least some of the open pores with bioactive, resorbable ceramic microspheres; interconnecting a plurality resorbable fibers to define a flexible scaffolding material having a plurality of open pores; and filling at least some of the open pores with bioactive, resorbable ceramic microspheres to define a tissue regrowth scaffolding material; filing a wound with tissue regrowth scaffolding material; wherein the fibers are characterized by fiber diameters substantially ranging from about 5 nanometers to about 10 micrometers; wherein the microspheres are characterized by diameters ranging up to about 3 millimeters; and wherein the interconnected fibers are able to move relative to one another.
-
Specification