METHODS AND SYSTEMS FOR CHEMICAL ABLATION
First Claim
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1. A thermochemical ablation system, comprising:
- a percutaneous fluid delivery cannula comprising first and second lumens extending from a proximal portion to a distal portion, the distal portion comprising a first side port in fluid communication with at least the first lumen and a second side port in fluid communication with at least the second lumen;
a first reservoir that contains a reducing agent so as to communicate the reducing agent through the first lumen to the distal portion of the percutaneous fluid delivery cannula, at least a portion of the reducing agent being deliverable out of the first side port; and
a second reservoir that contains an oxidizing agent so as to communicate the oxidizing agent through the second lumen to the distal portion of the percutaneous fluid delivery cannula, at least a portion of the oxidizing agent being deliverable out of the second side port to react with the reducing agent at the distal portion and generate an exothermic redox reaction.
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Abstract
Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.
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Citations
34 Claims
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1. A thermochemical ablation system, comprising:
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a percutaneous fluid delivery cannula comprising first and second lumens extending from a proximal portion to a distal portion, the distal portion comprising a first side port in fluid communication with at least the first lumen and a second side port in fluid communication with at least the second lumen; a first reservoir that contains a reducing agent so as to communicate the reducing agent through the first lumen to the distal portion of the percutaneous fluid delivery cannula, at least a portion of the reducing agent being deliverable out of the first side port; and a second reservoir that contains an oxidizing agent so as to communicate the oxidizing agent through the second lumen to the distal portion of the percutaneous fluid delivery cannula, at least a portion of the oxidizing agent being deliverable out of the second side port to react with the reducing agent at the distal portion and generate an exothermic redox reaction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for thermochemical ablation of targeted tissue, comprising:
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delivering a reducing agent through a first lumen of a percutaneous injection needle; delivering an oxidizing agent through a second lumen of the percutaneous injection needle; simultaneously infusing the oxidizing and reducing agents into targeted tissue to mix the oxidizing and reducing agents at a distal portion of the injection needle, resulting in an exothermic redox reaction between the oxidizing and reducing agents. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A thermochemical ablation system, comprising:
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a percutaneous fluid delivery cannula comprising a lumen extending from a proximal portion to a distal portion, the distal portion comprising a port in fluid communication with the lumen; and a reservoir containing a reagent in fluid communication with the lumen of the percutaneous fluid delivery cannula, at least a portion of the reagent being deliverable out of the port so as to react with water present at the targeted site to locally generate heat sufficient to ablate bodily tissue proximate the distal portion of the percutaneous fluid delivery cannula. - View Dependent Claims (26, 27, 28, 29)
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30. A method for thermochemical ablation of targeted tissue, comprising:
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delivering a highly reactive reagent through a lumen of a percutaneous injection needle to a targeted tissue site; and reacting the delivered reagent with water at the targeted tissue location to locally generate ablation heat at the targeted tissue site. - View Dependent Claims (31, 32, 33, 34)
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Specification