TWO-STAGE RECONSTITUTING INJECTOR

• US 20140221916A1
• Filed: 04/04/2014
• Published: 08/07/2014
• Est. Priority Date: 05/03/2006
• Status: Active Grant

• Current Assignee: Antares Pharma Incorporated
• Original Assignee: Antares Pharma Incorporated
• Inventors: KRAMER, Thomas E., SADOWSKI, Peter L.
• Granted Patent: US 9,808,582 B2
• Time in Patent Office: Days
• US Class Current: 604/70
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/2474 with movable piercing means, e.g. ampoule remains fixed or steady
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2466 by piercing without internal pressure increase A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/31596 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: A61M 5/326 Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Abstract

An injector (10) for injecting a medicament into a patient. The injector includes a container (18) defining a first chamber (22), which contains a fluid therein, and a second chamber (23). The injector also includes an injection conduit (126) configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source (62) is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.

Claims

1. An injector for injecting a medicament into a patient, comprising:

a container defining;

a first chamber containing a fluid, and

a second chamber;

an injection conduit configured for directing the fluid fired from the container into the patient;

a transfer mechanism operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation;

a firing mechanism operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation; and

an energy source in powering association with the transfer and firing mechanisms to drive transfer and firing mechanisms in both the first and second stages.

2. The injector of claim 1, further comprising an injection trigger mechanism operably associated with the firing mechanism to operate the firing mechanism in the second stage.

3. The injector of claim 2, wherein the transfer and firing mechanisms comprise a firing ram that is movable over a first throw in the first stage of operation and a second throw in the second stage of operation, the energy source in biasing association with the ram in each stage of operation to power the ram.

4. The injector of claim 3, wherein the injection trigger mechanism is configured to block movement of the ram beyond the first throw, the injection trigger being actuatable to release the ram to travel over the second throw.

5. The injector of claim 1, further comprising a retractable guard that is movable between:

a protecting position in which the injection conduit is disposed within the guard; and

an injecting position in which an injection needle portion of the injection conduit is exposed for injection of the fluid in the patient;

wherein the injection trigger mechanism is configured for operating the firing mechanism in the second stage after the retractable guard is retracted from the protecting position.

6. The injector of claim 5, wherein the retractable guard is operably associated with the injection trigger mechanism to cause the injection trigger mechanism to operate the firing mechanism when the guard is retracted to the injecting position.

7. The injector of claim 1, further comprising a transfer control that is manually operable to operate the injector in the first stage of operation, which further comprises venting the second chamber.

8. The injector of claim 1, wherein the injection conduit has a position that is fluidly incommunicated with the second chamber, the injector further comprising a transfer control that is manually operable to operate the transfer mechanism in the first stage of operation and to fluidly communicate the injection conduit with the second chamber in the first stage of operation.

9. The injector of claim 8, wherein the transfer control comprises a cap associated with the container and disposed to cover the injection conduit prior to the first stage of operation, which cap is separable from the injection conduit and container after the first stage of operation.

10. The injector of claim 8, wherein the injection conduit comprises a communicating needle portion, the transfer control operable to relatively move the communicating needle portion with respect to the second chamber to pierce the container to fluidly communicate the second chamber with the communicating needle portion in the first stage of operation.

11. The injector of claim 10, wherein the injection conduit comprises an injecting needle portion disposed and configured to pierce the skin of the patient for assisting the injection of the fluid in the second stage.

12. The injector of claim 11, wherein the energy source and firing mechanism are configured for delivering the fluid by jet injection to an injection site within the patient tissue remote from the injecting needle.

13. The injector of claim 10, wherein the injection conduit comprises a jet nozzle disposed and configured to deliver the fluid by jet injection into the patient during the second stage of operation to pierce the skin of the patient for assisting the injection of the fluid in the second stage.

14. The injector of claim 10, wherein the transfer control comprises a cap associated with the container and disposed to cover the injection conduit prior to the first stage of operation, which cap is separable from the injection conduit and container after the first stage of operation.

15. The injector of claim 14, further comprising a cap release in locking association with the cap to prevent operation thereof, and being positionable in a release position in which the cap release releases the cap to permit operation thereof in the first stage of operation.

16. The injector of claim 1, wherein the second chamber comprises a medicament, and the fluid comprises a diluent configured for dissolving or suspending the medicament therein for injection into the patient.

17. An injector for injecting a medicament into a patient, comprising:

a container defining;

a first chamber containing a fluid, and

a second chamber;

a firing mechanism configured for transferring the fluid from the first chamber to the second chamber in a first stage of operation, and for firing the fluid from the second chamber in a second stage of operation;

an injection conduit configured for directing the fluid fired from the container into the patient;

an energy source in powering association with the firing mechanism to drive firing mechanism in the first and second stages;

a trigger device associated with the energy source and the firing mechanism and being operable in a first triggering stage which causes the firing mechanism to operate in the first stage of operation, wherein the triggering device is configured such that after the firing mechanism has operated in the first stage of operation, the triggering device is operable in a second triggering stage which causes the firing mechanism to operate in the second stage of operation.

18. An injector for injecting medicament into a patient, comprising:

a container comprising a fluid chamber containing a medicament therein, the fluid chamber comprising a needle hub at the distal end thereof;

an injection conduit configured for directing the medicament fired from the container into the patient, the injection conduit having a position that is fluidly incommunicated with the fluid chamber;

a firing mechanism operable by the user for firing the medicament from the fluid chamber through the injection conduit;

an energy source in powering association with the firing mechanism to drive firing mechanism; and

a transfer control operable to fluidly communicate the injection conduit with the needle hub of the fluid chamber, the transfer control comprising a cap associated with the container and disposed to cover the injection conduit;

wherein the cap is separable from the injection conduit upon operating the transfer control to fluidly communicate the injection conduit with the needle hub.

19. The injector of claim 20, wherein the injection conduit comprises a communicating needle portion, the transfer control being operable to relatively move the communicating needle portion with respect to the fluid chamber to pierce the container adjacent the needle hub to fluidly communicate the fluid chamber with the communicating needle portion.