FASCIA FIBROUS COMPOSITIONS AND METHODS FOR THEIR USE AND MANUFACTURE

• US 20140271790A1
• Filed: 03/11/2014
• Published: 09/18/2014
• Est. Priority Date: 03/13/2013
• Status: Active Grant

• Current Assignee: AlloSource
• Original Assignee: AlloSource
• Inventors: Stevens, Peter J., Southard, Matthew, Samaniego, Adrian C.
• Granted Patent: US 9,446,077 B2
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A61K 35/35 Fat tissue; Adipocytes; Stromal cells; Connective tissues adipose-derived stem cells A61K35/28; collagen A61K38/39
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/3662 Ligaments, tendons
• CPC Class Codes: A61L 27/3687 characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
• CPC Class Codes: D01C 3/00 Treatment of animal material, e.g. chemical scouring of wool

Abstract

Embodiments of the present invention encompass fascia, fat, and dermis fibrous compositions, and methods for their manufacture and use. In a first aspect, embodiments of the present invention encompass methods for obtaining a fascia fiber for use in producing a biotextile. Exemplary methods may include treating a cadaveric fascia tissue with acetone, and obtaining the fascia fibers from the treated fascia tissue. In some cases, methods may include processing the fascia fibers to produce the fibrous fascia biotextile.

Claims

1. A method of producing a fibrous fascia biotextile composition, the method comprising:

obtaining a cadaveric fascia tissue;

treating the cadaveric fascia tissue with acetone;

obtaining fascia fibers from the treated cadaveric fascia tissue; and

processing the fascia fibers to produce the fibrous fascia biotextile.

2. The method of claim 1, wherein the method further comprises washing and clearing the cadaveric fascia tissue of biological fluids.

3. The method of claim 1, wherein the method further comprises exposing the cadaveric fascia tissue to a basic solution and an organic dehydrating solution before treating the cadaveric fascia tissue with acetone.

4. The method of claim 1, wherein the cadaveric fascia tissue comprises adipose oil and the method further comprises removing substantially all of the adipose oil.

5. The method of claim 1, wherein processing the fascia fibers comprises weaving, bundling, spinning, or carding.

6. The method of claim 1, wherein the fibrous fascia biotextile comprises sheets, bundles, and other three dimensional fibrous structures.

7. The method of claim 1, wherein the fibrous fascia biotextile comprises movable fiber configurations.

8. The method of claim 1, wherein the method further comprises adding a biological component selected from the group consisting of a stem cell composition, a polymer based support, a polymer based skeleton, and a bone construct to the fibrous fascia biotextile.

9. The method of claim 1, wherein the fibrous fascia biotextile comprises sutures, mats, felts, and pads for use in surgery.

10. The method of claim 1, wherein the fibrous fascia biotextile comprises gauzes, meshes, implants for use in facial ligament or tendon reconstruction, ligament/tendon bundles, fabric wraps, or fabric clamps.

11. A fibrous fascia biotextile composition, comprising:

a plurality of cadaveric fascia tissue fibers,

wherein the fibers are obtained from a cadaveric fascia tissue treated with acetone.

12. The composition of claim 11, wherein the composition further comprises a biological component selected from the group consisting of a stem cell composition, a polymer based support, a polymer based skeleton, and a bone construct containing cortical or cancellous bone material.

13. The composition of claim 11, wherein the composition is substantially clear of adipose oil.

14. The composition of claim 11, wherein the fascia tissue fibers comprise fascia tissue fibers from a thigh, a tendon, or a ligament.

15. A method of treating a patient with a fibrous fascia biotextile composition, the method comprising:

applying the fibrous fascia biotextile composition to a treatment site of the patient,

wherein the composition comprises a plurality of fascia tissue fibers obtained from an acetone-treated cadaveric fascia tissue.

16. The method of claim 15, wherein the treatment site of the patient comprises a tendon, a muscle, a ligament, or a form of cartilage.

17. The method of claim 15, wherein the fibrous fascia biotextile composition comprises a suture, a mesh, a fabric, or an implant.

18. The method of claim 15, wherein the fibrous fascia biotextile composition is substantially free of adipose oil.

19. The method of claim 15, wherein the treatment site of the patient comprises a hernia, a torn tendon, or a replaced tendon.

20. The method of claim 15, wherein applying the fibrous fascia biotextile composition comprises inhibiting bleeding or absorbing blood at the treatment site.