IN-VIVO DEVICE, SYSTEM AND METHOD FOR DETECTION OF HELICOBACTER PYLORI

• US 20140316222A1
• Filed: 04/23/2014
• Published: 10/23/2014
• Est. Priority Date: 04/23/2013
• Status: Abandoned Application

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: RABINOVITZ, Elisha, Sella-Tavor, Osnat
• Application Number:
  US14/259,946
• Publication Number:
  US 20140316222A1
• Time in Patent Office: Days
• US Class Current: 600/302
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

Device, system and method for in-vivo detection of H. pylori. For example, an in-vivo device includes a housing, a reference electrode disposed on the housing, and a working electrode disposed on the housing in close proximity to the reference electrode. The working electrode is coated by litography or screen printing with salt such that substantially no current passes between the working electrode and the reference electrode. The in-vivo device further includes a measuring device for measuring current, impedance, and/or resistance between the working and the reference electrodes, and a transmitter for transmitting the measurements. Presence of ammonia, which is a byproduct of H. pylori, causes increase in current and thus decrease in impedance or resistance between the reference electrode and the working electrode; thereby measurements of current, impedance, and/or resistance indicate on presence or absence of H. pylori.

Claims

1. An in-vivo device for in-vivo detection of H. pylori, said device comprising:

a housing;

a reference electrode disposed on the housing;

a working electrode disposed on the housing in close proximity to said reference electrode, said working electrode coated by litography or screen printing with salt dissolvable in the presence of ammonia such that substantially no current can pass between the working electrode and the reference electrode when coated;

a measuring device for measuring current, impedance and/or resistance between the working and the reference electrodes; and

a transmitter for transmitting said measurements .

2. The in-vivo device according to claim 1, wherein said in-vivo device further comprises a processor for processing the measurements into an indication of presence or absence of H. pylori.

3. The in-vivo device according to claim 1, wherein said measuring device is an ampere-meter.

4. The in-vivo device according to claim 1, wherein said in-vivo device is an autonomous swallowable device.

5. The in-vivo device according to claim 1, wherein said reference electrode is made of gold.

6. The in-vivo device according to claim 1, wherein said working electrode is made of gold.

7. The in-vivo device according to claim 1, wherein said working electrode is litography coated with silver-chloride salt.

8. The in-vivo device according to claim 1, wherein said working electrode is coated by screen printing with silver-chloride salt.

9. A system for in-vivo detection of H. pylori, said system comprising:

the in-vivo device according to claim 1;

a receiver for receiving the transmitted measurements of current, impedance, and/or resistance;

a processing unit for processing the received measurements and providing an indication on presence or absence of H. pylori; and

a display unit for displaying said current, impedance, and/or resistance measurements along with the indication on presence or absence of H. pylori.

10. An in-vivo device for in-vivo detection of H. pylori, said device comprising:

a housing;

a gap through which in-vivo fluids may enter and exit;

a mixture of substrate and enzyme for reacting with ammonia, which causes the substrate to change its optical properties;

an illumination source for illuminating said mixture, said illumination source located on one side of the gap;

a detector for detecting the change in optical properties of the substrate that indicate presence of H. pylori, wherein said detector is located on an opposite side of the gap and facing across the gap towards the illumination source; and

a transmitter for transmitting said detected changes in optical properties that indicate presence of H. pylori.

11. The in-vivo device according to claim 10, wherein said change in optical property of the substrate is a change in light absorbance by the substrate.

12. The in-vivo device according to claim 10, wherein said in-vivo device is an autonomous swallowable device.

13. A system for in-vivo detection of H. pylori, said system comprising:

an in-vivo device according to claim 10;

a receiver for receiving the transmitted changes in optical properties;

a processing unit for processing the received changes in optical properties and determining presence or absence of H. pylori; and

a display unit for displaying said changes in optical properties along with determination of presence or absence of H. pylori.

14. A method for in-vivo detection of H. pylori, said method comprising the following steps:

administering into gastric fluids a swallowable in-vivo device comprising a reference electrode, a working electrode litography coated with salt, and an ampere-meter;

measuring current between the reference and working electrodes using said ampere-meter; and

determining presence of H. pylori in-vivo based on said current measurements.

15. The method according to claim 14, wherein an increase in current measurement between the reference and working electrodes indicates in-vivo presence of H. pylori.

16. A method for in-vivo detection of H. pylori, said method comprising the following steps:

administering in-vivo a swallowable device, said device comprising;

a gap, an illumination source located on one side of the gap, a detector located on the opposite side of the gap and facing across the gap towards said illumination source, and a substrate and enzyme located within the gap for detection of ammonia;

allowing flow of in-vivo fluids through the gap, and thus allowing contact between the substrate, enzyme, and ammonia; and

determining in-vivo presence of H. pylori, based on change in optical properties of the substrate.