SYSTEMS AND METHODS OF MULTISPECTRAL BLOOD MEASUREMENT

• US 20140316226A1
• Filed: 03/14/2014
• Published: 10/23/2014
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Itamar Medical SPRY 2021 Limited Partnership
• Original Assignee: Echo Labs, Inc. (Asahi Kasei Corporation)
• Inventors: Ferber, Elad, Cobut, Pierre-Jean
• Granted Patent: US 10,463,283 B2
• Time in Patent Office: Days
• US Class Current: 600/315
• CPC Class Codes: A61B 2560/045 with a separable interface unit, e.g. for communication
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/721 using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

An exemplary system comprises an energy transmitter, an energy receiver, and an analyzer. The energy transmitter may project energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with at least one nutrient of a set of nutrients in blood of the user. The energy receiver may generate a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user. The analyzer may separate the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength, and detect, in the blood of the user, a concentration of the at least one nutrient of the set of nutrients based on the first signal and the second signal.

Claims

1. A system comprising:

an energy transmitter configured to project energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with at least one nutrient of a set of nutrients in blood of the user;

an energy receiver configured to generate a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user; and

an analyzer configured to separate the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength, and to detect, in the blood of the user, a concentration of the at least one nutrient of the set of nutrients based on the first signal and the second signal.

2. The system of claim 1, wherein the fraction of the energy is received by the energy receiver after the fraction of the energy is reflected by the tissue of the user.

3. The system of claim 1, further comprising a wearable member, wherein the energy transmitter and the energy receiver are secured to the wearable member such that the energy transmitter and the energy receiver are in contact or in proximity with the tissue.

4. The system of claim 1, wherein the analyzer is further configured to determine a set of blood metrics based on the first signal and the second signal the concentration of at least one nutrient of the set of nutrients being determined based on the determined set of blood metrics.

5. The system of claim 4, further comprising a user interface configured to display at least some of the set of blood metrics.

6. The system of claim 4, wherein the analyzer is further configured to compare a blood metric of the set of blood metric to a threshold and to generate an alert if the blood metric exceeds the threshold.

7. The system of claim 4, wherein the set of blood metrics comprises a blood glucose concentration.

8. The system of claim 1, wherein the analyzer is further configured to determine a first AC component and a first DC component of the first signal, to determine a second AC component and a second DC component of the second signal, wherein the concentration of a nutrient of the set of nutrients is detected based on the first AC component, the first DC component, the second AC component, and the second DC component.

9. The system of claim 1, further comprises a motion detector configured to measure a level of motion, and the analyzer is configured to compare the level of motion to a threshold and to discount a measurement of the composite signal when the level of motion exceeds the threshold.

10. The system of claim 1, wherein a nutrient of the set of nutrients comprises glucose.

11. A method comprising:

projecting energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with at least one nutrient of a set of nutrients in blood of the user;

generating a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user;

separating the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength; and

detecting, in the blood of the user, a concentration of the at least one nutrient of the set of nutrients based on the first signal and the second signal.

12. The method of claim 11, wherein the fraction of the energy is received by the energy receiver after the fraction of the energy is reflected by the tissue of the user.

13. The method of claim 11, further comprising determining the concentration of the at least one nutrient of the set of nutrients based on a determination of a set of blood metrics.

14. The method of claim 13, further comprising displaying at least some of the set of blood metrics.

15. The method of claim 13, further comprising comparing a blood metric of the set of blood metrics to a threshold and generating an alert if the blood metric exceeds the threshold.

16. The method of claim 13, wherein the set of blood metrics comprises a blood glucose concentration.

17. The method of claim 11, further comprising determining a first AC component and a first DC component of the first signal, determining a second AC component and a second DC component of the second signal, wherein the concentration of a nutrient of the set of nutrients is detected based on the first AC component, the first DC component, the second AC component, and the second DC component.

18. The method of claim 11, further comprising measuring a level of motion, comparing the level of motion to a threshold, and removing a measurement of the composite signal when the level of motion exceeds the threshold.

19. The method of claim 11, wherein a nutrient of the set of nutrients comprises glucose.

20. A system comprising:

an energy transmitter configured to project energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with, in blood of the user, at least component, the at least one component being at least one of one of glucose, hemoglobin, triglycerides, cholesterol, bilirubin, protein, albumin, blood pH, Hematocrit, cortisol, and/or electrolytes;

an energy receiver configured to generate a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user; and

an analyzer configured to separate the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength, and to detect, in the blood of the user, a concentration of the at least one component based on the first signal and the second signal.