SYSTEMS AND METHODS ENABLING HIGH-THROUGHPUT, REAL TIME DETECTION OF ANALYTES
First Claim
1. A system for detecting an analyte comprising:
- a plasmonic interferometer, the plasmonic interferometer comprising a first surface having a first scattering element and a second scattering element and an aperture disposed between the first scattering element and the second scattering element to define a first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element, wherein the first and second distances are selected to provide interference of light at the aperture;
a light source for illuminating the first surface of the plasmonic interferometer;
a detector positioned for detecting light transmitted through the aperture; and
a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer.
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Abstract
System and methods for detecting analytes are provided. The system includes a plasmonic interferometer with a first surface having a first and second scattering element and an aperture disposed between the first scattering element and the second scattering element. A first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element are selected to provide interference of light at the slit. The system also includes a light source for illuminating the first surface of the plasmonic interferometer, a detector positioned for detecting light transmitted through the aperture, and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer.
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Citations
44 Claims
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1. A system for detecting an analyte comprising:
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a plasmonic interferometer, the plasmonic interferometer comprising a first surface having a first scattering element and a second scattering element and an aperture disposed between the first scattering element and the second scattering element to define a first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element, wherein the first and second distances are selected to provide interference of light at the aperture; a light source for illuminating the first surface of the plasmonic interferometer; a detector positioned for detecting light transmitted through the aperture; and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 43, 44)
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36. A system for detecting a plurality of analytes comprising:
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a plurality of plasmonic interferometers, each plasmonic interferometer comprising; a first surface having a first scattering element and a second scattering element; and an aperture disposed between the first scattering element and the second scattering element to define a first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element; wherein the first and second distances are selected to provide controlled interference of light at the aperture; a light source for illuminating the first surface of each of the plurality of plasmonic interferometers; a plurality of detectors positioned for detecting light transmitted through the aperture of each plasmonic interferometer; and a plurality of sample holders, each sample holder disposing a sample to be analyzed onto the first surface of each plasmonic interferometer. - View Dependent Claims (37, 38, 39, 40, 41)
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42. A system for detecting an analyte comprising:
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a plasmonic interferometer, the plasmonic interferometer comprising a first surface having a first scattering element and a second scattering element and an aperture disposed between the first scattering element and the second scattering element to define a first distance between the aperture and the first scattering element and a second distance between the aperture and the second scattering element, wherein the first and second distances are selected to provide constructive interference of light at the aperture; a light source for illuminating the first surface of the plasmonic interferometer; a detector positioned for detecting light transmitted through the aperture; and a sample holder for disposing a sample to be analyzed onto the first surface of the plasmonic interferometer; wherein the sample comprises an oxidative or chromogenic dye selected to absorb particular light frequencies.
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Specification