IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NEUTICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY
First Claim
1. A contact lens formed from reactive components comprising about 0.1 to about 10 mmol/100 gm reactive mixture of at least one anionic component comprising at least one carboxylic acid group and at least one silicone component selected from the group consisting of reactive polydialkylsiloxane selected from compounds of Formula I:
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Abstract
The present invention relates to ionic silicone hydrogel polymers displaying improved thermal stability. More specifically, the present invention relates to a polymer formed from reactive components comprising at least one silicone component and at least one ionic component comprising at least one anionic group. The polymers of the present invention display good thermal stability and desirable protein uptake.
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Citations
30 Claims
- 1. A contact lens formed from reactive components comprising about 0.1 to about 10 mmol/100 gm reactive mixture of at least one anionic component comprising at least one carboxylic acid group and at least one silicone component selected from the group consisting of reactive polydialkylsiloxane selected from compounds of Formula I:
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30. A contact lens formed by polymerizing components comprising at least one silicone component and at least one ionic component comprising at least one carboxylic acid group in molar concentrations up to about 9.3 mmol/100 gm and wherein said contact lens absorbs at least about 10 μ
- g lysozyme, less than about 5 μ
g lipocalin and wherein at least about 50% of proteins absorbed in or on said contact lens are in native form.
- g lysozyme, less than about 5 μ
Specification