METHOD AND NEUROPROSTHETIC DEVICE FOR MONITORING AND SUPPRESSION OF PATHOLOGICAL TREMORS THROUGH NEUROSTIMULATION OF THE AFFERENT PATHWAYS

• US 20140336722A1
• Filed: 05/07/2014
• Published: 11/13/2014
• Est. Priority Date: 05/08/2013
• Status: Active Application

• Current Assignee: Consejo Superior de Investigaciones Científicas,, Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin (Georg-August-Universität Göttingen)
• Original Assignee: Consejo Superior de Investigaciones Científicas,, Georg-August-Universität Göttingen
• Inventors: ROCON DE LIMA, Eduardo, PONS ROVIRA, Jose Luis, FARINA, Dario, DOSEN, Strahinja
• Application Number:
  US14/271,669
• Publication Number:
  US 20140336722A1
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36031 using physiological parameters for adjustment
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer

Abstract

Method and neuroprosthetic device for monitoring and suppression of pathological tremors in a user through the neurostimulation of the afferent pathways to the brain, which comprises wearable elements placed over the parts of the body affected by tremor, wherein said wearable elements (1) have sensors selected from bioelectric sensors (3) generating a bioelectrical signal characterization of tremor, biomechanical sensors (4) generating a biomechanical signal characterization of tremor and a combination thereof, a programmable electronic device (9) comprised of a control, acquisition and processing module of the characterization signals, and a signal generator for the afferent stimulation based on the bioelectrical, biomechanical or combination of both signal characterization and stimulation electrodes (8) which transmit the neuromodulation signals to the afferent pathways projecting into the central nervous system to modulate the activity of the neural structures responsible for tremor generation.

Claims

1. Neuroprosthetic device for monitoring and suppression of pathological tremor in a user via stimulation of the afferent pathways, characterized by comprising at least one wearable element located on the user, wherein the wearable element comprises:

At least one sensor selected from at least one bioelectrical sensor that generates a bioelectrical characterization signal of the tremor, at least one biomechanical sensor that generates a biomechanical characterization signal of the tremor and a combination thereof;

A programmable electronic device comprising at least one control, acquisition and processing module for receiving and analyzing the bioelectrical characterization signals, the biomechanical characterization signals or the combination of both characterization signals, an electric signal generator for generating a signal of the afferent nerve stimulation based on the bioelectric, biomechanical or both characterization signals defined previously and,

At least one stimulation electrode integrated in the wearable element that generates the neuromodulation of the afferent pathways.

2. Neuroprosthetic device according to claim 1, characterized by comprising at least one EEG sensor which measures brain activity and generates a electroencephalography signal which characterizes intended voluntary movement of the user with the body part suffering from tremor.

3. Neuroprosthetic device according to claim 2, characterized by comprising an external device connectable to a programmable electronic device that implements an interface for accessing the functionalities of the at least one electroencephalography sensor and the wearable element.

4. Neuroprosthetic device according to claim 1, wherein at least one stimulation electrode is an electrode selected from an implanted electrode and a transcutaneous electrode.

5. Neuroprosthetic device according to claim 1, comprising at least one bioelectrical sensor selected from sensors of conventional and high resolution electromyography, electroencephalography sensors measuring brain activity and characterizing the user intention to move or a combination of those.

6. Neuroprosthetic device according to claim 1, comprising at least one biomechanical sensor which is an inertial sensor selected from gyroscopes, accelerometers, magnetometers or a combination of those.

7. Neuroprosthetic device according to claim 5, in which the electromyography sensors are multichannel thin film electrodes.

8. Neuroprosthetic device according to claim 1, wherein at least one stimulation electrode is a thin film multi-channel electrode.

9. Neuroprosthetic device according to claim 3, wherein the programmable electronic device is selected from a computer, a smartphone and a tablet device.

10. Neuroprosthetic device according to claim 3, wherein the connection between the programmable electronic device and the external device is selected from a wireless connection or a wired connection.

11. Neuroprosthetic device according to claim 3, wherein the external device comprises means for displaying measurements taken by the neuroprosthetic diagnostic device based on the available sensors, a processor for analysis of tremor and generation of diagnostics and reporting, and a memory storage for the measurements made by the neuroprosthetic device.

12. Neuroprosthetic device according to claim 9, wherein the connection between the programmable electronic device and the external device is selected from a wireless connection or a wired connection, and the external device comprises means for displaying measurements taken by the neuroprosthetic diagnostic device based on the available sensors, a processor for analysis of tremor and generation of diagnostics and reporting, and a memory storage for the measurements made by the neuroprosthetic device.

13. Method for monitoring and suppression of pathological tremor via the stimulation of the afferent pathways to the brain of the user, making use of the device described in claim 1, characterized by comprising the following stages:

i) characterizing the tremor by means of a plurality of bioelectric sensors generating a bioelectrical characterization of the tremor, biomechanical sensors generating a biomechanical characterization signal of the tremor, or a combination thereof, wherein the bioelectrical, biomechanical or both characterization signals comprises at least the instantaneous frequency, phase or amplitude of the tremor sending these bioelectrical, biomechanical or both characterization signals to the control, acquisition and processing module of the programmable electronic device;

ii) differentiating the tremor from the voluntary movement of the user through a conventional analysis of the bioelectrical, biomechanical or both characterization signals by the control, acquisition and processing module;

iii) calculating a neurostimulation signal from the signal characterization of tremor in the control, acquisition and processing module of the programmable electronic device;

iv) generating the neurostimulation signal through the signal generator module of the programmable electronic device and,

v) To generate the neurostimulation signal to the plurality of stimulation electrodes activating the afferent pathways.

14. Method for monitoring and suppression of pathological tremors according to claim 13, characterized in that when the device has at least one EEG sensor which measures brain activity of the user, the method comprises the following steps:

i) measuring, additionally to step i) the user'"'"'s brain activity by at least one EEG sensor and generating the electroencephalography signal that characterizes the intention of the user to perform a voluntary movement of the limb affected by tremor;

ii) sending, additionally in Phase II), the electroencephalography signal to the control, acquisition and processing module of the programmable electronic device;

iii) To distinguish, additionally in Phase III), the tremor from the voluntary movement of the user through a conventional analysis of the electroencephalography signal, and,

iv) To additionally employ EEG signal in step iv) to calculate the neurostimulation signal.

15. Method for monitoring and suppression of pathological tremors, according to claims 13, wherein the neurostimulation signal generate an afferent input flow to the central nervous system that disrupts the low-frequency synchronization in the corticobasal ganglia circuits.

16. Method for monitoring and suppression of pathological tremors according to claim 13, wherein the conventional analysis employed by the programmable electronic device for differentiating the tremor from the voluntary movement is based on algorithms in the time and frequency domain.

17. Method for monitoring and suppression of pathological tremors according to claim 14, wherein the neurostimulation signal generates an afferent input flow to the central nervous system that disrupts the low-frequency synchronization in the corticobasal ganglia circuits, and the conventional analysis employed by the programmable electronic device for differentiating the tremor from the voluntary movement is based on algorithms in the time and frequency domain.

18. Method for monitoring and suppression of pathological tremor via the stimulation of the afferent pathways to the brain of the user, making use of the device described in claim 2, characterized by comprising the following stages:

i) characterizing the tremor by means of a plurality of bioelectric sensors generating a bioelectrical characterization of the tremor, biomechanical sensors generating a biomechanical characterization signal of the tremor, or a combination thereof, wherein the bioelectrical, biomechanical or both characterization signals comprises at least the instantaneous frequency, phase or amplitude of the tremor sending these bioelectrical, biomechanical or both characterization signals to the control, acquisition and processing module of the programmable electronic device;

ii) differentiating the tremor from the voluntary movement of the user through a conventional analysis of the bioelectrical, biomechanical or both characterization signals by the control, acquisition and processing module;

iii) calculating a neurostimulation signal from the signal characterization of tremor in the control, acquisition and processing module of the programmable electronic device;

iv) generating the neurostimulation signal through the signal generator module of the programmable electronic device and,

v) To generate the neurostimulation signal to the plurality of stimulation electrodes activating the afferent pathways.

19. Method for monitoring and suppression of pathological tremor via the stimulation of the afferent pathways to the brain of the user, making use of the device described in claim 3, characterized by comprising the following stages:

i) characterizing the tremor by means of a plurality of bioelectric sensors generating a bioelectrical characterization of the tremor, biomechanical sensors generating a biomechanical characterization signal of the tremor, or a combination thereof, wherein the bioelectrical, biomechanical or both characterization signals comprises at least the instantaneous frequency, phase or amplitude of the tremor sending these bioelectrical, biomechanical or both characterization signals to the control, acquisition and processing module of the programmable electronic device;

ii) differentiating the tremor from the voluntary movement of the user through a conventional analysis of the bioelectrical, biomechanical or both characterization signals by the control, acquisition and processing module;

iii) calculating a neurostimulation signal from the signal characterization of tremor in the control, acquisition and processing module of the programmable electronic device;

iv) generating the neurostimulation signal through the signal generator module of the programmable electronic device and,

v) To generate the neurostimulation signal to the plurality of stimulation electrodes activating the afferent pathways.

20. Method for monitoring and suppression of pathological tremor via the stimulation of the afferent pathways to the brain of the user, making use of the device described in claim 4, characterized by comprising the following stages:

i) characterizing the tremor by means of a plurality of bioelectric sensors generating a bioelectrical characterization of the tremor, biomechanical sensors generating a biomechanical characterization signal of the tremor, or a combination thereof, wherein the bioelectrical, biomechanical or both characterization signals comprises at least the instantaneous frequency, phase or amplitude of the tremor sending these bioelectrical, biomechanical or both characterization signals to the control, acquisition and processing module of the programmable electronic device;

ii) differentiating the tremor from the voluntary movement of the user through a conventional analysis of the bioelectrical, biomechanical or both characterization signals by the control, acquisition and processing module;

iii) calculating a neurostimulation signal from the signal characterization of tremor in the control, acquisition and processing module of the programmable electronic device;

iv) generating the neurostimulation signal through the signal generator module of the programmable electronic device and,

v) To generate the neurostimulation signal to the plurality of stimulation electrodes activating the afferent pathways.